KRAS (GeneID: 3845) | Homo sapiens
Description: KRAS proto-oncogene, GTPase [Source:HGNC Symbol;Acc:HGNC:6407]
Synonyms: K-RAS2B, c-Ki-ras2, NS, -RAS4A, KI-RAS, K-RAS2A, RALD, C-K-RAS, KRAS2, K-RAS4B, CFC2, NS3, ASK2, KRAS1
Other ID(s): ENSG00000133703, HGNC:6407
Protein Accession Numbers: NP_001356716, ENST00000556131, ENST00000256078, NP_203524, NP_001356715, ENST00000311936, NP_004976, ENST00000557334, ENST00000256078.4
Statistics: ClinVar(190) gnomAD(92) COSMIC(21186) PTM(21)
ClinVar Pathogenicity of Variations help

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000256078 You are here now! ENST00000311936 ENST00000556131 ENST00000557334 NP_001356715 You are here now! NP_001356716 NP_004976 NP_203524 You are here now!


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00071 Ras Ras family 5-165 CL0023 P-loop_NTPase Homo sapiens

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Adenocarcinoma Neoplasms ; 0.35 0.724
Adenoma Neoplasms ; 0.35 0.724
Anemia Hemic and Lymphatic Diseases ; 0.35 0.724
Astrocytoma Neoplasms ; 0.35 0.724
Malignant neoplasm of urinary bladder Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.35 0.724
Bladder Neoplasm Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.35 0.724
Malignant neoplasm of breast Neoplasms ; Skin and Connective Tissue Diseases ; 0.35 0.724
Malignant Neoplasms Neoplasms ; 0.35 0.724
Carcinoma Neoplasms ; 0.35 0.724
Malignant tumor of colon Neoplasms ; Digestive System Diseases ; 0.35 0.724
Malignant neoplasm of thyroid N/A 0.35 0.724
Non-Small Cell Lung Carcinoma Neoplasms ; Respiratory Tract Diseases ; 0.35 0.724
Squamous cell carcinoma Neoplasms ; 0.35 0.724
Cecal Neoplasms Neoplasms ; Digestive System Diseases ; 0.35 0.724
Neoplastic Cell Transformation Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.35 0.724
Intracranial Arteriovenous Malformation Nervous System Diseases ; Cardiovascular Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
Malignant tumor of cervix N/A 0.35 0.724
Uterine Cervical Neoplasm Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; 0.35 0.724
Charcot-Marie-Tooth Disease Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
Colonic Neoplasms Neoplasms ; Digestive System Diseases ; 0.35 0.724
Colorectal Carcinoma Neoplasms ; Digestive System Diseases ; 0.35 0.724
Colorectal Neoplasms Neoplasms ; Digestive System Diseases ; 0.35 0.724
Craniosynostosis Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
Cytopenia N/A 0.35 0.724
Endometriosis Female Urogenital Diseases and Pregnancy Complications ; 0.35 0.724
gallbladder neoplasm Neoplasms ; Digestive System Diseases ; 0.35 0.724
Hemangiosarcoma Neoplasms ; 0.35 0.724
Hepatoma, Morris Neoplasms ; Digestive System Diseases ; 0.35 0.724
Hepatoma, Novikoff Neoplasms ; Digestive System Diseases ; 0.35 0.724
Hydrops Fetalis Female Urogenital Diseases and Pregnancy Complications ; Hemic and Lymphatic Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Immune System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.35 0.724
Leukemia, Myelocytic, Acute Neoplasms ; 0.35 0.724
Leukemia, Myelomonocytic, Chronic Neoplasms ; Hemic and Lymphatic Diseases ; 0.35 0.724
Leukocytosis Hemic and Lymphatic Diseases ; Pathological Conditions, Signs and Symptoms ; 0.35 0.724
Liver Diseases, Parasitic Parasitic Diseases ; Digestive System Diseases ; 0.35 0.724
Liver neoplasms Neoplasms ; Digestive System Diseases ; 0.35 0.724
Liver Neoplasms, Experimental Neoplasms ; Digestive System Diseases ; 0.35 0.724
Lung Neoplasms Neoplasms ; Respiratory Tract Diseases ; 0.35 0.724
Lymphoma Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.35 0.724
Malignant neoplasm of stomach Neoplasms ; Digestive System Diseases ; 0.35 0.724
Mouth Neoplasms Neoplasms ; Stomatognathic Diseases ; 0.35 0.724
Multiple Myeloma Neoplasms ; Cardiovascular Diseases ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.35 0.724
Acute Myeloid Leukemia, M1 Neoplasms ; 0.35 0.724
Neoplasm Metastasis Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.35 0.724
Neoplasms Neoplasms ; 0.35 0.724
Neoplasms, Experimental Neoplasms ; 0.35 0.724
Neuroblastoma Neoplasms ; 0.35 0.724
Noonan Syndrome Musculoskeletal Diseases ; Cardiovascular Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.35 0.724
Osteogenesis Imperfecta Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.35 0.724
Ovarian Carcinoma N/A 0.35 0.724
Pancreatic Neoplasm Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.35 0.724
Penile Neoplasms Neoplasms ; Male Urogenital Diseases ; 0.35 0.724
Prostatic Neoplasms Neoplasms ; Male Urogenital Diseases ; 0.35 0.724
Splenomegaly Pathological Conditions, Signs and Symptoms ; 0.35 0.724
Stomach Neoplasms Neoplasms ; Digestive System Diseases ; 0.35 0.724
Thyroid Neoplasm Neoplasms ; Endocrine System Diseases ; 0.35 0.724
Turner Syndrome, Male Musculoskeletal Diseases ; Cardiovascular Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.35 0.724
Uterine Neoplasms Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; 0.35 0.724
Experimental Hepatoma Neoplasms ; Digestive System Diseases ; 0.35 0.724
Benign Neoplasm Neoplasms ; 0.35 0.724
Juvenile-Onset Still Disease Musculoskeletal Diseases ; Skin and Connective Tissue Diseases ; Immune System Diseases ; 0.35 0.724
Squamous cell carcinoma of lung N/A 0.35 0.724
Thyroid Gland Follicular Adenoma Neoplasms ; Endocrine System Diseases ; 0.35 0.724
Pleocytosis Hemic and Lymphatic Diseases ; Pathological Conditions, Signs and Symptoms ; 0.35 0.724
Adenocarcinoma of lung (disorder) Neoplasms ; Respiratory Tract Diseases ; 0.35 0.724
Malignant neoplasm of mouth Neoplasms ; Stomatognathic Diseases ; 0.35 0.724
Malignant neoplasm of cecum Neoplasms ; Digestive System Diseases ; 0.35 0.724
Malignant neoplasm of gallbladder Neoplasms ; Digestive System Diseases ; 0.35 0.724
Uterine Cancer Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; 0.35 0.724
Malignant neoplasm of penis Neoplasms ; Male Urogenital Diseases ; 0.35 0.724
Congenital anemia N/A 0.35 0.724
Adenocarcinoma, Basal Cell Neoplasms ; 0.35 0.724
Adenocarcinoma, Oxyphilic Neoplasms ; 0.35 0.724
Carcinoma, Cribriform Neoplasms ; 0.35 0.724
Carcinoma, Granular Cell Neoplasms ; 0.35 0.724
Adenocarcinoma, Tubular Neoplasms ; 0.35 0.724
Adenoma, Basal Cell Neoplasms ; 0.35 0.724
Follicular adenoma Neoplasms ; 0.35 0.724
Adenoma, Microcystic Neoplasms ; 0.35 0.724
Adenoma, Monomorphic Neoplasms ; 0.35 0.724
Papillary adenoma Neoplasms ; 0.35 0.724
Adenoma, Trabecular Neoplasms ; 0.35 0.724
Anaplastic carcinoma Neoplasms ; 0.35 0.724
Carcinoma, Spindle-Cell Neoplasms ; 0.35 0.724
Undifferentiated carcinoma Neoplasms ; 0.35 0.724
Carcinomatosis Neoplasms ; 0.35 0.724
Subependymal Giant Cell Astrocytoma Neoplasms ; 0.35 0.724
Follicular thyroid carcinoma Neoplasms ; 0.35 0.724
Cholangiocarcinoma Neoplasms ; 0.35 0.724
Pancreatic carcinoma Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.35 0.724
Gastrointestinal Stromal Tumors Neoplasms ; Digestive System Diseases ; 0.35 0.724
Papillary thyroid carcinoma Neoplasms ; Endocrine System Diseases ; 0.35 0.724
Malignant neoplasm of lung Neoplasms ; Respiratory Tract Diseases ; 0.35 0.724
Organoid Nevus Phakomatosis Neoplasms ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
Endometrioma Female Urogenital Diseases and Pregnancy Complications ; 0.35 0.724
Transitional cell carcinoma of bladder N/A 0.35 0.724
Juvenile Pilocytic Astrocytoma Neoplasms ; 0.35 0.724
Diffuse Astrocytoma Neoplasms ; 0.35 0.724
Cervix carcinoma N/A 0.35 0.724
Anaplastic astrocytoma Neoplasms ; 0.35 0.724
Protoplasmic astrocytoma Neoplasms ; 0.35 0.724
Gemistocytic astrocytoma Neoplasms ; 0.35 0.724
Fibrillary Astrocytoma Neoplasms ; 0.35 0.724
Pilocytic Astrocytoma Neoplasms ; 0.35 0.724
Childhood Cerebral Astrocytoma Neoplasms ; 0.35 0.724
Malignant neoplasm of liver Neoplasms ; Digestive System Diseases ; 0.35 0.724
Intrahepatic Cholangiocarcinoma Neoplasms ; 0.35 0.724
Malignant neoplasm of pancreas Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.35 0.724
Benign tumor of pancreas N/A 0.35 0.724
Juvenile Myelomonocytic Leukemia Neoplasms ; Hemic and Lymphatic Diseases ; 0.35 0.724
Verrucous epidermal nevus Neoplasms ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
Malignant neoplasm of prostate Neoplasms ; Male Urogenital Diseases ; 0.35 0.724
Encephalocraniocutaneous lipomatosis Nervous System Diseases ; Eye Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; Nutritional and Metabolic Diseases ; 0.35 0.724
Inflammatory linear verrucous epidermal nevus Neoplasms ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
Neoplasm of uncertain or unknown behavior of ovary N/A 0.35 0.724
Neoplasm of uncertain or unknown behavior of breast N/A 0.35 0.724
Epileptic encephalopathy N/A 0.35 0.724
Mixed oligoastrocytoma Neoplasms ; 0.35 0.724
Thyroid carcinoma Neoplasms ; Endocrine System Diseases ; 0.35 0.724
Costello syndrome (disorder) Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
Carcinogenesis Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.35 0.724
Breast Carcinoma Neoplasms ; Skin and Connective Tissue Diseases ; 0.35 0.724
Carcinoma of lung N/A 0.35 0.724
Stomach Carcinoma N/A 0.35 0.724
Cerebral Astrocytoma Neoplasms ; 0.35 0.724
Intracranial Astrocytoma Neoplasms ; 0.35 0.724
Intracranial Arteriovenous Malformation, Ruptured Nervous System Diseases ; Cardiovascular Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
Carcinoma in situ of uterine cervix Neoplasms ; 0.35 0.724
Breast adenocarcinoma N/A 0.35 0.724
Carcinoma, Pancreatic Ductal Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.35 0.724
Arteriovenous Malformations, Cerebral Nervous System Diseases ; Cardiovascular Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
ovarian neoplasm Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.35 0.724
Hereditary non-polyposis colorectal cancer syndrome N/A 0.35 0.724
Malignant neoplasm of ovary Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.35 0.724
Mammary Neoplasms, Human Neoplasms ; Skin and Connective Tissue Diseases ; 0.35 0.724
Cardio-facio-cutaneous syndrome Cardiovascular Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; Pathological Conditions, Signs and Symptoms ; 0.35 0.724
Adenocarcinoma of large intestine N/A 0.35 0.724
Hereditary Nonpolyposis Colorectal Cancer Neoplasms ; Digestive System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Nutritional and Metabolic Diseases ; 0.35 0.724
Mammary Neoplasms Neoplasms ; Skin and Connective Tissue Diseases ; 0.35 0.724
Colorectal Cancer Neoplasms ; Digestive System Diseases ; 0.35 0.724
Female Pseudo-Turner Syndrome Musculoskeletal Diseases ; Cardiovascular Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.35 0.724
Grade I Astrocytoma Neoplasms ; 0.35 0.724
Hereditary Diffuse Gastric Cancer Neoplasms ; Digestive System Diseases ; 0.35 0.724
APLASIA CUTIS CONGENITA WITH EPIBULBAR DERMOIDS Neoplasms ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.35 0.724
NOONAN SYNDROME 3 Musculoskeletal Diseases ; Cardiovascular Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.35 0.724
Acute Myeloid Leukemia (AML-M2) Neoplasms ; 0.35 0.724
MYOPATHY, CONGENITAL, WITH EXCESS OF MUSCLE SPINDLES Musculoskeletal Diseases ; Nervous System Diseases ; 0.35 0.724
Liver carcinoma Neoplasms ; Digestive System Diseases ; 0.35 0.724
RAS-ASSOCIATED AUTOIMMUNE LEUKOPROLIFERATIVE DISORDER N/A 0.35 0.724
Hematopoetic Myelodysplasia Hemic and Lymphatic Diseases ; 0.35 0.724
Pancreatic carcinoma, familial Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.35 0.724
Nasopharyngeal carcinoma Neoplasms ; Stomatognathic Diseases ; Otorhinolaryngologic Diseases ; 0.35 0.724
GASTRIC CANCER, INTESTINAL N/A 0.35 0.724
Linear Verrucous Epidermal Nevus Neoplasms ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
MYELODYSPLASTIC SYNDROME Hemic and Lymphatic Diseases ; 0.35 0.724
Juvenile arthritis Musculoskeletal Diseases ; Skin and Connective Tissue Diseases ; Immune System Diseases ; 0.35 0.724
Intellectual Disability Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; Mental Disorders ; 0.35 0.724
Juvenile psoriatic arthritis Musculoskeletal Diseases ; Skin and Connective Tissue Diseases ; Immune System Diseases ; 0.35 0.724
Extrahepatic Cholangiocarcinoma Neoplasms ; 0.35 0.724
CARDIOFACIOCUTANEOUS SYNDROME 2 N/A 0.35 0.724
Nevus sebaceous Neoplasms ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.35 0.724
NO RESULT FOUND
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