MET (GeneID: 4233) | Homo sapiens
Description: MET proto-oncogene, receptor tyrosine kinase [Source:HGNC Symbol;Acc:HGNC:7029]
Synonyms: HGFR, AUTS9, DFNB97, RCCP2, c-Met
Other ID(s): HGNC:7029, ENSG00000105976
Protein Accession Numbers: ENST00000539704, ENST00000436117, NP_001120972, ENST00000318493.6, ENST00000456159, NP_001311331, ENST00000422097, NP_000236, ENST00000318493, ENST00000454623, NP_001311330, ENST00000397752
Statistics: ClinVar(1302) gnomAD(981) COSMIC(1426) PTM(73)
ClinVar Pathogenicity of Variations help

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000318493 ENST00000397752 You are here now! ENST00000422097 ENST00000436117 ENST00000454623 ENST00000456159 ENST00000539704 NP_000236 You are here now! NP_001120972 NP_001311330 NP_001311331


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF01403 Sema Sema domain 54-493 Homo sapiens
PF01437 PSI Plexin repeat 519-562 CL0630 PSI Homo sapiens
PF01833 TIG IPT/TIG domain 563-654 CL0159 E-set Homo sapiens
PF01833 TIG IPT/TIG domain 657-738 CL0159 E-set Homo sapiens
PF01833 TIG IPT/TIG domain 742-833 CL0159 E-set Homo sapiens
PF07714 PK_Tyr_Ser-Thr Protein tyrosine and serine/threonine kinase 1078-1337 CL0016 PKinase Homo sapiens

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Adenocarcinoma Neoplasms ; 0.405 0.793
Astrocytoma Neoplasms ; 0.405 0.793
Autistic Disorder Mental Disorders ; 0.405 0.793
Malignant Neoplasms Neoplasms ; 0.405 0.793
Carcinoma Neoplasms ; 0.405 0.793
Non-Small Cell Lung Carcinoma Neoplasms ; Respiratory Tract Diseases ; 0.405 0.793
Renal Cell Carcinoma Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.405 0.793
Squamous cell carcinoma Neoplasms ; 0.405 0.793
Cognition Disorders Mental Disorders ; 0.405 0.793
Esophageal Neoplasms Neoplasms ; Digestive System Diseases ; 0.405 0.793
Glioblastoma Neoplasms ; 0.405 0.793
Hepatitis, Chronic Digestive System Diseases ; 0.405 0.793
Hepatoma, Morris Neoplasms ; Digestive System Diseases ; 0.405 0.793
Hepatoma, Novikoff Neoplasms ; Digestive System Diseases ; 0.405 0.793
Leukemia, Myelocytic, Acute Neoplasms ; 0.405 0.793
Liver Neoplasms, Experimental Neoplasms ; Digestive System Diseases ; 0.405 0.793
Lung Neoplasms Neoplasms ; Respiratory Tract Diseases ; 0.405 0.793
Malignant neoplasm of stomach Neoplasms ; Digestive System Diseases ; 0.405 0.793
Acute Myeloid Leukemia, M1 Neoplasms ; 0.405 0.793
Neoplasm Invasiveness Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.405 0.793
Neoplasm Metastasis Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.405 0.793
Neuroblastoma Neoplasms ; 0.405 0.793
Osteosarcoma Neoplasms ; 0.405 0.793
Prostatic Neoplasms Neoplasms ; Male Urogenital Diseases ; 0.405 0.793
Schizophrenia Mental Disorders ; 0.405 0.793
Sinusitis Respiratory Tract Diseases ; Otorhinolaryngologic Diseases ; 0.405 0.793
Stomach Neoplasms Neoplasms ; Digestive System Diseases ; 0.405 0.793
Experimental Hepatoma Neoplasms ; Digestive System Diseases ; 0.405 0.793
Chronic Persistent Hepatitis Digestive System Diseases ; 0.405 0.793
Benign neoplasm of stomach N/A 0.405 0.793
Benign neoplasm of adrenal gland N/A 0.405 0.793
Benign neoplasm of aortic body and other paraganglia N/A 0.405 0.793
Carcinoma in situ of stomach N/A 0.405 0.793
Adenocarcinoma, Basal Cell Neoplasms ; 0.405 0.793
Adenocarcinoma, Oxyphilic Neoplasms ; 0.405 0.793
Carcinoma, Cribriform Neoplasms ; 0.405 0.793
Carcinoma, Granular Cell Neoplasms ; 0.405 0.793
Adenocarcinoma, Tubular Neoplasms ; 0.405 0.793
Anaplastic carcinoma Neoplasms ; 0.405 0.793
Carcinoma, Spindle-Cell Neoplasms ; 0.405 0.793
Undifferentiated carcinoma Neoplasms ; 0.405 0.793
Carcinomatosis Neoplasms ; 0.405 0.793
Subependymal Giant Cell Astrocytoma Neoplasms ; 0.405 0.793
Hepatoblastoma Neoplasms ; 0.405 0.793
Malignant neoplasm of lung Neoplasms ; Respiratory Tract Diseases ; 0.405 0.793
Childhood Hepatocellular Carcinoma N/A 0.405 0.793
Conventional (Clear Cell) Renal Cell Carcinoma Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.405 0.793
Juvenile Pilocytic Astrocytoma Neoplasms ; 0.405 0.793
Diffuse Astrocytoma Neoplasms ; 0.405 0.793
Anaplastic astrocytoma Neoplasms ; 0.405 0.793
Protoplasmic astrocytoma Neoplasms ; 0.405 0.793
Gemistocytic astrocytoma Neoplasms ; 0.405 0.793
Fibrillary Astrocytoma Neoplasms ; 0.405 0.793
Pilocytic Astrocytoma Neoplasms ; 0.405 0.793
Giant Cell Glioblastoma Neoplasms ; 0.405 0.793
Childhood Cerebral Astrocytoma Neoplasms ; 0.405 0.793
Malignant Adrenal Medulla Neoplasm N/A 0.405 0.793
Malignant neoplasm of liver Neoplasms ; Digestive System Diseases ; 0.405 0.793
Malignant mesothelioma Neoplasms ; Respiratory Tract Diseases ; 0.405 0.793
Malignant neoplasm of prostate Neoplasms ; Male Urogenital Diseases ; 0.405 0.793
Malignant neoplasm of aortic body and other paraganglia N/A 0.405 0.793
Neoplasm of uncertain or unknown behavior of stomach N/A 0.405 0.793
Chronic active hepatitis Digestive System Diseases ; 0.405 0.793
Cryptogenic Chronic Hepatitis Digestive System Diseases ; 0.405 0.793
Malignant neoplasm of esophagus Neoplasms ; Digestive System Diseases ; 0.405 0.793
Mixed oligoastrocytoma Neoplasms ; 0.405 0.793
Stomach Carcinoma N/A 0.405 0.793
Malignant neoplasm of kidney Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.405 0.793
Cerebral Astrocytoma Neoplasms ; 0.405 0.793
Intracranial Astrocytoma Neoplasms ; 0.405 0.793
Hereditary Papillary Renal Carcinoma N/A 0.405 0.793
ovarian neoplasm Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.405 0.793
Malignant neoplasm of ovary Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.405 0.793
Squamous cell carcinoma of the head and neck Neoplasms ; 0.405 0.793
Chromophobe Renal Cell Carcinoma Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.405 0.793
Sarcomatoid Renal Cell Carcinoma Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.405 0.793
Collecting Duct Carcinoma of the Kidney Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.405 0.793
Papillary Renal Cell Carcinoma Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.405 0.793
Adenocarcinoma of large intestine N/A 0.405 0.793
Type 1 Papillary Renal Cell Carcinoma N/A 0.405 0.793
Glioblastoma Multiforme Neoplasms ; 0.405 0.793
Grade I Astrocytoma Neoplasms ; 0.405 0.793
Hereditary Diffuse Gastric Cancer Neoplasms ; Digestive System Diseases ; 0.405 0.793
Osteofibrous Dysplasia Musculoskeletal Diseases ; 0.405 0.793
Tibia, Bowing of, with Pseudarthrosis and Pectus Excavatum Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Wounds and Injuries ; 0.405 0.793
Copper-Overload Cirrhosis Digestive System Diseases ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Nutritional and Metabolic Diseases ; 0.405 0.793
Acute Myeloid Leukemia (AML-M2) Neoplasms ; 0.405 0.793
Liver carcinoma Neoplasms ; Digestive System Diseases ; 0.405 0.793
Hepatoblastoma Caused By Somatic Mutation Neoplasms ; Digestive System Diseases ; 0.405 0.793
Papillary renal cell carcinoma, familial Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.405 0.793
Intellectual Disability Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; Mental Disorders ; 0.405 0.793
DEAFNESS, AUTOSOMAL RECESSIVE 97 N/A 0.405 0.793
OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO N/A 0.405 0.793
NO RESULT FOUND
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