ConVarT

ClinVar Data

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Variation ID	Allele ID	RS Number	Variant Type	Record	Alteration	Clinicial Sig.	Last Update	Phenotypes	Cytogenetic	Review Status	RCV Acc.N.

gnomAD

Frameshift Variant

Missense Variant

Splice Region Variant

Start Lost

Stop Gained

Synonymous Variant

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Variant ID	Transcript ID	Alteration	Annotation	Allele C.	Allele N.	Allele F.	rsNumber	Filter
3-172224680-T-C	ENST00000420541	p.Ala100Ala	Synonymous Variant	1	31396	0.000032	rs760642981
3-172224682-C-A	ENST00000420541	p.Ala100Ser	Missense Variant	0	0	0	rs756475262
3-172224682-C-T	ENST00000420541	p.Ala100Thr	Missense Variant	0	0	0	rs756475262
3-172224683-G-A	ENST00000420541	p.Ala99Ala	Synonymous Variant	1	31384	0.000032	rs764242132
3-172224684-G-T	ENST00000420541	p.Ala99Asp	Missense Variant	0	0	0	rs1210123919
3-172224687-C-G	ENST00000420541	p.Trp98Ser	Missense Variant	0	0	0	rs754015822
3-172224689-G-T	ENST00000420541	p.Leu97Leu	Synonymous Variant	0	0	0	rs371357466
3-172224706-G-A	ENST00000420541	p.Pro92Ser	Missense Variant	0	0	0	rs1210164777
3-172232651-C-A	ENST00000420541	p.Lys90Asn	Missense Variant	1	31396	0.000032	rs760670084
3-172232651-C-T	ENST00000420541	p.Lys90Lys	Splice Region Variant	1	31396	0.000032	rs760670084
3-172232659-C-T	ENST00000420541	p.Val88Ile	Missense Variant	3	31394	0.000096	rs140214406
3-172232660-G-A	ENST00000420541	p.Leu87Leu	Synonymous Variant	1	31396	0.000032	rs1291288240	RF
3-172232662-G-C	ENST00000420541	p.Leu87Val	Missense Variant	0	0	0	rs1038334232
3-172232664-T-C	ENST00000420541	p.Gln86Arg	Missense Variant	0	0	0	rs753678205
3-172232667-C-T	ENST00000420541	p.Arg85His	Missense Variant	0	0	0	rs757021342
3-172232668-G-A	ENST00000420541	p.Arg85Cys	Missense Variant	5	31388	0.000159	rs764907364
3-172232669-G-T	ENST00000420541	p.Leu84Leu	Synonymous Variant	0	0	0	rs1181817019
3-172232671-G-A	ENST00000420541	p.Leu84Phe	Missense Variant	0	0	0	rs750051656
3-172232672-T-C	ENST00000420541	p.Gln83Gln	Synonymous Variant	2	31360	0.000064	rs757869963
3-172232675-C-G	ENST00000420541	p.Trp82Cys	Missense Variant	0	0	0	rs1471740683

Showing 1 to 20 of 104 entries

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Post-translational Modifications (PTMs)

Phosphorylation

Ubiquitination

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Gene Name	ACC ID	PTM Type	Position	Mod-rsd	Site +/-7 Aa	Mw_kd	Site grpID
TNFSF10	P50591	Ubiquitination	106	K106-ub	TISTVQEkQQNISPL	32.51	573764998
TNFSF10	P50591	Phosphorylation	133	S133-p	ITGTRGRsNtLSSPN	32.51	23155010
TNFSF10	P50591	Phosphorylation	135	T135-p	GTRGRsNtLSSPNSK	32.51	3825502
TNFSF10	P50591	Phosphorylation	213	Y213-p	MVQYIYKytSYPDPI	32.51	13831800
TNFSF10	P50591	Phosphorylation	214	T214-p	VQYIYKytSYPDPIL	32.51	13831803
TNFSF10	P50591	Phosphorylation	225	S225-p	DPILLMKsARNSCWS	32.51	23155012

Showing 1 to 6 of 6 entries

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Catalogue of Somatic Mutations in Cancer (COSMIC)

Substitution - Coding Silent

Substitution - Missense

Unknown

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Gene Name	Transcript ID	Sample name	Primary Site	Primary Histology	Mutation ID	Mutation CDS	Mutation Aa	Mutation Desc.	FATHMM Prediction	FATHMM Score	Mutation Somatic Status	PUBMED PMID	Tumor Origin	Position
TNFSF10_ENST00000420541	ENST00000420541	TCGA-MH-A855-01	kidney	carcinoma	50739406	c.168T>C	p.C56=	Substitution - coding silent	NEUTRAL	.48133	Confirmed somatic variant	PMID: N/A	primary	56
TNFSF10_ENST00000420541	ENST00000420541	SC_9061	prostate	carcinoma	50739663	c.*480C>G	p.?	Unknown	NEUTRAL	.00245	Confirmed somatic variant	PMID: 26000489	metastasis	0
TNFSF10_ENST00000420541	ENST00000420541	11M	skin	malignant_melanoma	50739512	c.149C>T	p.S50F	Substitution - Missense	PATHOGENIC	.84893	Confirmed somatic variant	PMID: 26343386	NS	50
TNFSF10_ENST00000420541	ENST00000420541	8066067	pancreas	carcinoma	50738455	c.270+3083C>G	p.?	Unknown	NEUTRAL	.01366	Confirmed somatic variant	PMID: N/A	NS	0
TNFSF10_ENST00000420541	ENST00000420541	MELA_32178	skin	malignant_melanoma	50738596	c.*280G>A	p.?	Unknown	PATHOGENIC	.91935	Confirmed somatic variant	PMID: 30178487	metastasis	0
TNFSF10_ENST00000420541	ENST00000420541	TCGA-G7-6796-01	kidney	carcinoma	50739376	c.217A>G	p.M73V	Substitution - Missense	NEUTRAL	.04208	Confirmed somatic variant	PMID: N/A	NS	73
TNFSF10_ENST00000420541	ENST00000420541	PD6720a	breast	carcinoma	50739526	c.271-3877C>T	p.?	Unknown	NEUTRAL	.01864	Confirmed somatic variant	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	TCGA-AB-2868-03	haematopoietic_and_lymphoid_tissue	haematopoietic_neoplasm	50738352	c.*133T>A	p.?	Unknown	NEUTRAL	.024	Confirmed somatic variant	PMID: N/A	NS	0
TNFSF10_ENST00000420541	ENST00000420541	TCGA-G3-A7M9-01	liver	carcinoma	50739724	c.*420T>G	p.?	Unknown	NEUTRAL	.06744	Confirmed somatic variant	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	PD6415a	breast	carcinoma	50739368	c.132+1595G>A	p.?	Unknown	NEUTRAL	.00237	Confirmed somatic variant	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	TCGA-A6-6648-01	large_intestine	carcinoma	50738556	c.132+3983G>T	p.?	Unknown	NEUTRAL	.08265	Confirmed somatic variant	PMID: 22810696	NS	0
TNFSF10_ENST00000420541	ENST00000420541	HCC84T	liver	carcinoma	50738449	c.271-2107A>G	p.?	Unknown	NEUTRAL	.03268	Variant of unknown origin	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	PD18730a	breast	carcinoma	50738931	c.*623C>T	p.?	Unknown	NEUTRAL	.02925	Confirmed somatic variant	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	PD18730a	breast	carcinoma	50738927	c.*937C>G	p.?	Unknown	NEUTRAL	.00399	Confirmed somatic variant	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	TCGA-EE-A2MR-06	skin	malignant_melanoma	50738127	c.*103C>T	p.?	Unknown	PATHOGENIC	.97414	Confirmed somatic variant	PMID: N/A	NS	0
TNFSF10_ENST00000420541	ENST00000420541	0188_CRUK_PC_0188_T1_DNA	prostate	carcinoma	50740013	c.133-2985A>C	p.?	Unknown	NEUTRAL	.05559	Confirmed somatic variant	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	BD98T	biliary_tract	carcinoma	50738885	c.133-3371C>A	p.?	Unknown	NEUTRAL	.04406	Confirmed somatic variant	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	T3670	large_intestine	carcinoma	50738702	c.270+3222G>A	p.?	Unknown	PATHOGENIC	.80808	Confirmed somatic variant	PMID: 27149842	NS	0
TNFSF10_ENST00000420541	ENST00000420541	HCC76T	liver	carcinoma	50738530	c.133-3303C>A	p.?	Unknown	NEUTRAL	.10406	Variant of unknown origin	PMID: N/A	primary	0
TNFSF10_ENST00000420541	ENST00000420541	TCGA-61-1998-01	ovary	carcinoma	50738772	c.36G>A	p.L12=	Substitution - coding silent	NEUTRAL	.05369	Confirmed somatic variant	PMID: 21720365	primary	12

Showing 1 to 20 of 130 entries

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dbSNP

Gene ID	Transcript ID	Consequence	Position	HGVSp	Impact

Protein Domains (PFAM)

Pfam Domain	Domain Name	Description	Positions	Clan	Clan Name	Organism
NO RESULT FOUND
PF00229	TNF	TNF(Tumour Necrosis Factor) family	152-280	CL0100	C1q_TNF	Homo sapiens

List of the diseases from DisGeNET

Disease Name	Disease Category	DSI*	DPI**
Spontaneous abortion	Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Abortion, Tubal	Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Malignant neoplasm of breast	Neoplasms ; Skin and Connective Tissue Diseases ;	0.44	0.828
Malignant tumor of colon	Neoplasms ; Digestive System Diseases ;	0.44	0.828
Renal Cell Carcinoma	Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Colonic Neoplasms	Neoplasms ; Digestive System Diseases ;	0.44	0.828
Colorectal Carcinoma	Neoplasms ; Digestive System Diseases ;	0.44	0.828
Colorectal Neoplasms	Neoplasms ; Digestive System Diseases ;	0.44	0.828
Endometrial Neoplasms	Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Glioblastoma	Neoplasms ;	0.44	0.828
Glioma	Neoplasms ;	0.44	0.828
Influenza	Virus Diseases ; Respiratory Tract Diseases ;	0.44	0.828
Kidney Neoplasm	Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
leukemia	Neoplasms ;	0.44	0.828
Leukemia, Myelocytic, Acute	Neoplasms ;	0.44	0.828
Liver neoplasms	Neoplasms ; Digestive System Diseases ;	0.44	0.828
Mammary Neoplasms, Experimental	Neoplasms ;	0.44	0.828
Acute Myeloid Leukemia, M1	Neoplasms ;	0.44	0.828
Neoplasm Metastasis	Neoplasms ; Pathological Conditions, Signs and Symptoms ;	0.44	0.828
Neoplasms, Experimental	Neoplasms ;	0.44	0.828
Pathologic Neovascularization	Pathological Conditions, Signs and Symptoms ;	0.44	0.828
Neuroblastoma	Neoplasms ;	0.44	0.828
Pancreatic Neoplasm	Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ;	0.44	0.828
Prostatic Neoplasms	Neoplasms ; Male Urogenital Diseases ;	0.44	0.828
Injuries, Acute Brain	Nervous System Diseases ; Wounds and Injuries ;	0.44	0.828
Adenocarcinoma of lung (disorder)	Neoplasms ; Respiratory Tract Diseases ;	0.44	0.828
mixed gliomas	Neoplasms ;	0.44	0.828
Brain Injuries	Nervous System Diseases ; Wounds and Injuries ;	0.44	0.828
Brain Lacerations	Nervous System Diseases ; Wounds and Injuries ;	0.44	0.828
Conventional (Clear Cell) Renal Cell Carcinoma	Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Giant Cell Glioblastoma	Neoplasms ;	0.44	0.828
Malignant neoplasm of liver	Neoplasms ; Digestive System Diseases ;	0.44	0.828
Malignant neoplasm of pancreas	Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ;	0.44	0.828
Malignant neoplasm of prostate	Neoplasms ; Male Urogenital Diseases ;	0.44	0.828
Brain Injuries, Focal	Nervous System Diseases ; Wounds and Injuries ;	0.44	0.828
Endometrial Carcinoma	Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Malignant Glioma	Neoplasms ;	0.44	0.828
Breast Carcinoma	Neoplasms ; Skin and Connective Tissue Diseases ;	0.44	0.828
Malignant neoplasm of kidney	Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
ovarian neoplasm	Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ;	0.44	0.828
Malignant neoplasm of ovary	Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ;	0.44	0.828
Mammary Neoplasms, Human	Neoplasms ; Skin and Connective Tissue Diseases ;	0.44	0.828
Chromophobe Renal Cell Carcinoma	Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Sarcomatoid Renal Cell Carcinoma	Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Collecting Duct Carcinoma of the Kidney	Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Papillary Renal Cell Carcinoma	Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ;	0.44	0.828
Mammary Neoplasms	Neoplasms ; Skin and Connective Tissue Diseases ;	0.44	0.828
Colorectal Cancer	Neoplasms ; Digestive System Diseases ;	0.44	0.828
Glioblastoma Multiforme	Neoplasms ;	0.44	0.828
Acute Myeloid Leukemia (AML-M2)	Neoplasms ;	0.44	0.828
Liver carcinoma	Neoplasms ; Digestive System Diseases ;	0.44	0.828
NO RESULT FOUND

Description:	TNF superfamily member 10 [Source:ZFIN;Acc:ZDB-GENE-040718-335]
Synonyms:	tnfsf10l2, zgc:92320
Other ID(s):	ZDB-GENE-040718-335, ENSDARG00000057241
Protein Accession Numbers:	NP_001315456, NP_001002593
Statistics:	ClinVar(3) gnomAD(104) COSMIC(130) PTM(6)

Classification of Clinicial Significance of ClinVar Data