ConVarT

ClinVar Data

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Variation ID	Allele ID	RS Number	Variant Type	Record	Alteration	Clinicial Sig.	Last Update	Phenotypes	Cytogenetic	Review Status	RCV Acc.N.

gnomAD

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Variant ID	Transcript ID	Alteration	Annotation	Allele C.	Allele N.	Allele F.	rsNumber	Flags	Filter
No data available in table

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Post-translational Modifications (PTMs)

Phosphorylation

Ubiquitination

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Gene Name	ACC ID	PTM Type	Position	Mod-rsd	Site +/-7 Aa	Mw_kd	Site grpID
CNR2	P34972	Phosphorylation	114	T114-p	LLKIGSVtMTFTASV	39.68	25287658
CNR2	P34972	Phosphorylation	137	Y137-p	DRYLCLRyPPSyKAL	39.68	3659232
CNR2	P34972	Phosphorylation	141	Y141-p	CLRyPPSyKALLTRG	39.68	3659238
CNR2	P34972	Phosphorylation	268	S268-p	VLALMAHsLATTLSD	39.68	23094874
CNR2	P34972	Phosphorylation	29	S29-p	MKDYMILsGPQKTAV	39.68	23094877
CNR2	P34972	Phosphorylation	326	S326-p	KCVRGLGsEAkEEAP	39.68	5881586
CNR2	P34972	Ubiquitination	329	K329-ub	RGLGsEAkEEAPRss	39.68	573763446
CNR2	P34972	Phosphorylation	335	S335-p	AkEEAPRssVtEtEA	39.68	4707555
CNR2	P34972	Phosphorylation	336	S336-p	kEEAPRssVtEtEAD	39.68	4707561
CNR2	P34972	Phosphorylation	338	T338-p	EAPRssVtEtEADGk	39.68	3949257
CNR2	P34972	Phosphorylation	340	T340-p	PRssVtEtEADGkIT	39.68	4707567
CNR2	P34972	Ubiquitination	345	K345-ub	tEtEADGkITPWPDs	39.68	964507364
CNR2	P34972	Phosphorylation	352	S352-p	kITPWPDsRDLDLSD	39.68	450818

Showing 1 to 13 of 13 entries

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Catalogue of Somatic Mutations in Cancer (COSMIC)

Deletion - Frameshift

Substitution - Coding Silent

Substitution - Missense

Substitution - Nonsense

Unknown

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Gene Name	Transcript ID	Sample name	Primary Site	Primary Histology	Mutation ID	Mutation CDS	Mutation Aa	Mutation Desc.	FATHMM Prediction	FATHMM Score	Mutation Somatic Status	PUBMED PMID	Tumor Origin	Position
CNR2	ENST00000536471	0213_CRUK_PC_0213_T1_DNA	prostate	carcinoma	80563178	c.-45-13851T>G	p.?	Unknown	NEUTRAL	.03302	Confirmed somatic variant	PMID: N/A	primary	0
CNR2	ENST00000536471	COCA-CN-B-BcaA	large_intestine	carcinoma	80562201	c.-46+20399C>A	p.?	Unknown	NEUTRAL	.00003	Confirmed somatic variant	PMID: N/A	primary	0
CNR2	ENST00000536471	PD24199a	breast	carcinoma	80563537	c.-46+29581C>T	p.?	Unknown	NEUTRAL	.00255	Confirmed somatic variant	PMID: N/A	NS	0
CNR2	ENST00000536471	0154_CRUK_PC_0154_T1_DNA	prostate	carcinoma	80562848	c.-122-3798C>T	p.?	Unknown	NEUTRAL	.00533	Confirmed somatic variant	PMID: N/A	primary	0
CNR2	ENST00000536471	CPCG0183-F1	prostate	carcinoma	80562672	c.-45-5541C>T	p.?	Unknown	NEUTRAL	.00221	Confirmed somatic variant	PMID: N/A	NS	0
CNR2	ENST00000536471	TCGA-D3-A5GO-06	skin	malignant_melanoma	80561940	c.258C>T	p.V86=	Substitution - coding silent	PATHOGENIC	.79815	Confirmed somatic variant	PMID: N/A	NS	86
CNR2	ENST00000536471	6	skin	carcinoma	80560777	c.174C>T	p.I58=	Substitution - coding silent	PATHOGENIC	.70197	Confirmed somatic variant	PMID: 27592799	primary	58
CNR2	ENST00000536471	TCGA-D3-A5GO-06	skin	malignant_melanoma	80561929	c.879G>A	p.M293I	Substitution - Missense	PATHOGENIC	.70775	Confirmed somatic variant	PMID: N/A	NS	293
CNR2	ENST00000536471	084T	liver	carcinoma	80562578	c.911G>T	p.G304V	Substitution - Missense	NEUTRAL	.46289	Confirmed somatic variant	PMID: 23788652	primary	304
CNR2	ENST00000536471	PD9467a	breast	carcinoma	80562010	c.-45-25278T>A	p.?	Unknown	NEUTRAL	.0014	Confirmed somatic variant	PMID: N/A	NS	0
CNR2	ENST00000536471	5-VS056-T1	skin	carcinoma	80563168	c.318C>T	p.F106=	Substitution - coding silent	PATHOGENIC	.8183	Confirmed somatic variant	PMID: 26950094	NS	106
CNR2	ENST00000536471	TCGA-DK-AA6U-01	urinary_tract	carcinoma	80561760	c.1004C>A	p.S335Y	Substitution - Missense	PATHOGENIC	.89169	Confirmed somatic variant	PMID: N/A	primary	335
CNR2	ENST00000536471	TCGA-DK-AA6U-01	urinary_tract	carcinoma	80561772	c.934C>G	p.H312D	Substitution - Missense		.61243	Confirmed somatic variant	PMID: N/A	primary	312
CNR2	ENST00000536471	PD13767a	breast	carcinoma	80562130	c.-46+34969C>G	p.?	Unknown	NEUTRAL	.00887	Confirmed somatic variant	PMID: N/A	NS	0
CNR2	ENST00000536471	TCGA-C5-A2LS-01	cervix	carcinoma	80560887	c.482C>T	p.S161L	Substitution - Missense	PATHOGENIC	.85089	Confirmed somatic variant	PMID: N/A	primary	161
CNR2	ENST00000536471	RK101_C01	liver	carcinoma	80564599	c.-45-9766A>G	p.?	Unknown	NEUTRAL	.00456	Confirmed somatic variant	PMID: N/A	NS	0
CNR2	ENST00000536471	PD23558a	breast	carcinoma	80564538	c.-46+34841G>T	p.?	Unknown	NEUTRAL	.00158	Confirmed somatic variant	PMID: N/A	NS	0
CNR2	ENST00000536471	PD6722a	breast	carcinoma	80563953	c.-46+24885G>C	p.?	Unknown	NEUTRAL	.01113	Confirmed somatic variant	PMID: N/A	primary	0
CNR2	ENST00000536471	8065126	pancreas	carcinoma	80561740	c.-45-22027A>G	p.?	Unknown	NEUTRAL	.00689	Confirmed somatic variant	PMID: N/A	primary	0
CNR2	ENST00000536471	EXTERN_MELA_20140526_075	skin	malignant_melanoma	80563283	c.1038C>T	p.I346=	Substitution - coding silent	PATHOGENIC	.88831	Confirmed somatic variant	PMID: 28467829	metastasis	346

Showing 1 to 20 of 391 entries

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dbSNP

Gene ID	Transcript ID	Consequence	Position	HGVSp	Impact

Protein Domains (PFAM)

Pfam Domain	Domain Name	Description	Positions	Clan	Clan Name	Organism
NO RESULT FOUND
PF00001	7tm_1	7 transmembrane receptor (rhodopsin family)	50-299	CL0192	GPCR_A	Homo sapiens

List of the diseases from DisGeNET

Disease Name	Disease Category	DSI*	DPI**
Alcoholic Intoxication, Chronic	Chemically-Induced Disorders ; Mental Disorders ;	0.554	0.621
Atherosclerosis	Cardiovascular Diseases ;	0.554	0.621
Bipolar Disorder	Mental Disorders ;	0.554	0.621
Malignant neoplasm of breast	Neoplasms ; Skin and Connective Tissue Diseases ;	0.554	0.621
Mental Depression	Behavior and Behavior Mechanisms ;	0.554	0.621
Endogenous depression	Mental Disorders ;	0.554	0.621
Depressive disorder	Mental Disorders ;	0.554	0.621
Hyperalgesia	Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ;	0.554	0.621
Immune System Diseases	Immune System Diseases ;	0.554	0.621
Leukemia, Myelocytic, Acute	Neoplasms ;	0.554	0.621
Liver Cirrhosis	Digestive System Diseases ;	0.554	0.621
Marijuana Abuse	Chemically-Induced Disorders ; Mental Disorders ;	0.554	0.621
Melancholia	Mental Disorders ;	0.554	0.621
Acute Myeloid Leukemia, M1	Neoplasms ;	0.554	0.621
Pancreatic Neoplasm	Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ;	0.554	0.621
Pancreatitis	Digestive System Diseases ;	0.554	0.621
Secondary Parkinson Disease	Nervous System Diseases ;	0.554	0.621
Schizophrenia	Mental Disorders ;	0.554	0.621
Unipolar Depression	Mental Disorders ;	0.554	0.621
Alcohol abuse	Chemically-Induced Disorders ; Mental Disorders ;	0.554	0.621
Depressive Syndrome	Mental Disorders ;	0.554	0.621
Fibrosis, Liver	Digestive System Diseases ;	0.554	0.621
Depression, Neurotic	Mental Disorders ;	0.554	0.621
Malignant neoplasm of pancreas	Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ;	0.554	0.621
Allodynia	Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ;	0.554	0.621
Breast Carcinoma	Neoplasms ; Skin and Connective Tissue Diseases ;	0.554	0.621
Hyperalgesia, Primary	Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ;	0.554	0.621
Hyperalgesia, Secondary	Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ;	0.554	0.621
Tactile Allodynia	Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ;	0.554	0.621
Hyperalgesia, Thermal	Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ;	0.554	0.621
Parkinson Disease, Secondary Vascular	Nervous System Diseases ;	0.554	0.621
Atherosclerotic Parkinsonism	Nervous System Diseases ;	0.554	0.621
Mammary Neoplasms, Human	Neoplasms ; Skin and Connective Tissue Diseases ;	0.554	0.621
Mammary Neoplasms	Neoplasms ; Skin and Connective Tissue Diseases ;	0.554	0.621
Atherogenesis	Cardiovascular Diseases ;	0.554	0.621
Acute Myeloid Leukemia (AML-M2)	Neoplasms ;	0.554	0.621
Mechanical Allodynia	Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ;	0.554	0.621
Cannabis use	N/A	0.554	0.621
NO RESULT FOUND

Description:	cannabinoid receptor 2 [Source:HGNC Symbol;Acc:HGNC:2160]
Synonyms:	CB-2, CX5, CB2
Other ID(s):	ENSG00000188822, HGNC:2160
Protein Accession Numbers:	ENST00000536471, ENST00000374472, NP_001832
Statistics:	ClinVar(3) COSMIC(391) PTM(13)

Classification of Clinicial Significance of ClinVar Data