STAT3 (GeneID: 6774) | Homo sapiens
Description: signal transducer and activator of transcription 3 [Source:HGNC Symbol;Acc:HGNC:11364]
Synonyms: HIES, ADMIO, APRF, ADMIO1
Other ID(s): HGNC:11364, ENSG00000168610
Protein Accession Numbers: ENST00000264657, NP_001356443, NP_001371917, NP_998827, ENST00000588969, NP_001371914, NP_001371922, ENST00000404395, NP_001356446, NP_001371919, NP_001356442, NP_001371916, NP_644805, ENST00000588065, NP_001371913, NP_001371921, ENST00000389272, NP_001356445, NP_001371918, NP_001356441, NP_001371915, NP_003141, ENST00000585517, NP_001356447, NP_001371920
Statistics: ClinVar(627) gnomAD(339) COSMIC(621) PTM(68)
ClinVar Pathogenicity of Variations help

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000264657 ENST00000389272 ENST00000404395 You are here now! ENST00000585517 ENST00000588065 ENST00000588969 NP_001356441 NP_001356442 NP_001356443 You are here now! NP_001356445 You are here now! NP_001356446 NP_001356447 NP_001371913 NP_001371914 NP_001371915 NP_001371916 NP_001371917 NP_001371918 NP_001371919 NP_001371920 NP_001371921 NP_001371922 NP_003141 You are here now! NP_644805 NP_998827


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00017 SH2 SH2 domain 584-674 CL0541 SH2-like Homo sapiens
PF01017 STAT_alpha STAT protein, all-alpha domain 145-313 Homo sapiens
PF02864 STAT_bind STAT protein, DNA binding domain 325-464 CL0073 P53-like Homo sapiens
PF02865 STAT_int STAT protein, protein interaction domain 2-120 Homo sapiens

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Adenocarcinoma Neoplasms ; 0.358 0.862
Arthritis, Adjuvant-Induced Musculoskeletal Diseases ; 0.358 0.862
Atherosclerosis Cardiovascular Diseases ; 0.358 0.862
Autoimmune Diseases Immune System Diseases ; 0.358 0.862
Malignant neoplasm of breast Neoplasms ; Skin and Connective Tissue Diseases ; 0.358 0.862
Carcinoma Neoplasms ; 0.358 0.862
Malignant tumor of colon Neoplasms ; Digestive System Diseases ; 0.358 0.862
Non-Small Cell Lung Carcinoma Neoplasms ; Respiratory Tract Diseases ; 0.358 0.862
Squamous cell carcinoma Neoplasms ; 0.358 0.862
Neoplastic Cell Transformation Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Brain Ischemia Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Uterine Cervical Neoplasm Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; 0.358 0.862
Ulcerative Colitis Digestive System Diseases ; 0.358 0.862
Colonic Neoplasms Neoplasms ; Digestive System Diseases ; 0.358 0.862
Craniosynostosis Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.358 0.862
Depressive disorder Mental Disorders ; 0.358 0.862
Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases ; Endocrine System Diseases ; Immune System Diseases ; 0.358 0.862
Fever Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Fibrosis Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Cardiomegaly Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Hepatitis, Chronic Digestive System Diseases ; 0.358 0.862
Hepatoma, Morris Neoplasms ; Digestive System Diseases ; 0.358 0.862
Hepatoma, Novikoff Neoplasms ; Digestive System Diseases ; 0.358 0.862
Inflammation Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Leukemia, Myelocytic, Acute Neoplasms ; 0.358 0.862
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Leukemia, T-Cell Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Adult T-Cell Lymphoma/Leukemia Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Liver neoplasms Neoplasms ; Digestive System Diseases ; 0.358 0.862
Liver Neoplasms, Experimental Neoplasms ; Digestive System Diseases ; 0.358 0.862
Lymphatic Metastasis Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Malignant neoplasm of stomach Neoplasms ; Digestive System Diseases ; 0.358 0.862
Animal Mammary Neoplasms Neoplasms ; Animal Diseases ; 0.358 0.862
Mammary Neoplasms, Experimental Neoplasms ; 0.358 0.862
Medulloblastoma Neoplasms ; 0.358 0.862
Memory Disorders Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.358 0.862
Acute Myeloid Leukemia, M1 Neoplasms ; 0.358 0.862
Neoplasm Metastasis Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Pustulosis of Palms and Soles Skin and Connective Tissue Diseases ; 0.358 0.862
Pancreatic Neoplasm Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.358 0.862
Precancerous Conditions Neoplasms ; 0.358 0.862
Cardiomyopathies, Primary Cardiovascular Diseases ; 0.358 0.862
Prostatic Neoplasms Neoplasms ; Male Urogenital Diseases ; 0.358 0.862
Psoriasis Skin and Connective Tissue Diseases ; 0.358 0.862
Reperfusion Injury Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Myocardial Diseases, Secondary Cardiovascular Diseases ; 0.358 0.862
Stomach Neoplasms Neoplasms ; Digestive System Diseases ; 0.358 0.862
T-Cell Lymphoma Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Experimental Hepatoma Neoplasms ; Digestive System Diseases ; 0.358 0.862
Juvenile-Onset Still Disease Musculoskeletal Diseases ; Skin and Connective Tissue Diseases ; Immune System Diseases ; 0.358 0.862
Chronic Persistent Hepatitis Digestive System Diseases ; 0.358 0.862
Adenocarcinoma, Basal Cell Neoplasms ; 0.358 0.862
Adenocarcinoma, Oxyphilic Neoplasms ; 0.358 0.862
Carcinoma, Cribriform Neoplasms ; 0.358 0.862
Carcinoma, Granular Cell Neoplasms ; 0.358 0.862
Adenocarcinoma, Tubular Neoplasms ; 0.358 0.862
Anaplastic carcinoma Neoplasms ; 0.358 0.862
Carcinoma, Spindle-Cell Neoplasms ; 0.358 0.862
Undifferentiated carcinoma Neoplasms ; 0.358 0.862
Carcinomatosis Neoplasms ; 0.358 0.862
Diabetes, Autoimmune Nutritional and Metabolic Diseases ; Endocrine System Diseases ; Immune System Diseases ; 0.358 0.862
Medullomyoblastoma Neoplasms ; 0.358 0.862
Ki-1+ Anaplastic Large Cell Lymphoma Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Memory impairment Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.358 0.862
Congenital diaphragmatic hernia Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Middle Cerebral Artery Syndrome Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Congenital hernia of foramen of Morgagni Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Congenital hernia of foramen of Bochdalek Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Childhood Medulloblastoma Neoplasms ; 0.358 0.862
Adult Medulloblastoma Neoplasms ; 0.358 0.862
Condition, Preneoplastic Neoplasms ; 0.358 0.862
Atrophic Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Brittle diabetes Nutritional and Metabolic Diseases ; Endocrine System Diseases ; Immune System Diseases ; 0.358 0.862
Malignant neoplasm of liver Neoplasms ; Digestive System Diseases ; 0.358 0.862
Malignant neoplasm of pancreas Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.358 0.862
Malignant neoplasm of prostate Neoplasms ; Male Urogenital Diseases ; 0.358 0.862
Hematologic Neoplasms Neoplasms ; Hemic and Lymphatic Diseases ; 0.358 0.862
Chronic active hepatitis Digestive System Diseases ; 0.358 0.862
Cryptogenic Chronic Hepatitis Digestive System Diseases ; 0.358 0.862
Breast Carcinoma Neoplasms ; Skin and Connective Tissue Diseases ; 0.358 0.862
Middle Cerebral Artery Thrombosis Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Middle Cerebral Artery Occlusion Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Desmoplastic Medulloblastoma Neoplasms ; 0.358 0.862
Age-Related Memory Disorders Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.358 0.862
Memory Disorder, Semantic Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.358 0.862
Memory Disorder, Spatial Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.358 0.862
Memory Loss Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.358 0.862
Middle Cerebral Artery Embolus Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Left Middle Cerebral Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Embolic Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Thrombotic Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Right Middle Cerebral Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
Cardiomyopathies Cardiovascular Diseases ; 0.358 0.862
Cerebral Ischemia Nervous System Diseases ; Cardiovascular Diseases ; 0.358 0.862
ovarian neoplasm Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.358 0.862
Arthritis, Collagen-Induced Musculoskeletal Diseases ; 0.358 0.862
Arthritis, Experimental Musculoskeletal Diseases ; 0.358 0.862
Malignant neoplasm of ovary Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.358 0.862
Squamous cell carcinoma of the head and neck Neoplasms ; 0.358 0.862
Mammary Carcinoma, Animal Neoplasms ; Animal Diseases ; 0.358 0.862
Mammary Neoplasms, Human Neoplasms ; Skin and Connective Tissue Diseases ; 0.358 0.862
Melanotic medulloblastoma Neoplasms ; 0.358 0.862
Cardiac Hypertrophy Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Mammary Neoplasms Neoplasms ; Skin and Connective Tissue Diseases ; 0.358 0.862
Atherogenesis Cardiovascular Diseases ; 0.358 0.862
Cirrhosis Pathological Conditions, Signs and Symptoms ; 0.358 0.862
Hereditary Diffuse Gastric Cancer Neoplasms ; Digestive System Diseases ; 0.358 0.862
DIABETES MELLITUS, PERMANENT NEONATAL Nutritional and Metabolic Diseases ; Endocrine System Diseases ; 0.358 0.862
Copper-Overload Cirrhosis Digestive System Diseases ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Nutritional and Metabolic Diseases ; 0.358 0.862
Acute Myeloid Leukemia (AML-M2) Neoplasms ; 0.358 0.862
T-Cell Large Granular Lymphocyte Leukemia Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Hyper-Immunoglobulin E Syndrome, Autosomal Recessive Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Hyper-Immunoglobulin E Syndrome, Autosomal Dominant Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Hyper-Ige Recurrent Infection Syndrome, Autosomal Dominant Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
Juvenile arthritis Musculoskeletal Diseases ; Skin and Connective Tissue Diseases ; Immune System Diseases ; 0.358 0.862
Juvenile psoriatic arthritis Musculoskeletal Diseases ; Skin and Connective Tissue Diseases ; Immune System Diseases ; 0.358 0.862
Diabetes Mellitus, Ketosis-Prone Nutritional and Metabolic Diseases ; Endocrine System Diseases ; Immune System Diseases ; 0.358 0.862
Job Syndrome Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.358 0.862
AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1 N/A 0.358 0.862
cervical cancer Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; 0.358 0.862
Familial Ménière disease N/A 0.358 0.862
NO RESULT FOUND
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