ConVarT

ClinVar Data

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Variation ID	Allele ID	RS Number	Variant Type	Record	Alteration	Clinicial Sig.	Last Update	Phenotypes	Cytogenetic	Review Status	RCV Acc.N.

gnomAD

Frameshift Variant

Inframe Deletion

Inframe Insertion

Missense Variant

Protein Altering Variant

Splice Region Variant

Start Lost

Stop Gained

Synonymous Variant

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Variant ID	Transcript ID	Alteration	Annotation	Allele C.	Allele N.	Allele F.	rsNumber
2-223436595-A-G	ENST00000281828	p.Leu589Leu	Synonymous Variant	0	0	0	rs751862914
2-223436599-G-C	ENST00000281828	p.Pro587Pro	Synonymous Variant	0	0	0	rs757554435
2-223436600-G-A	ENST00000281828	p.Pro587Leu	Missense Variant	1	31372	0.000032	rs1214748937
2-223436601-G-T	ENST00000281828	p.Pro587Thr	Missense Variant	0	0	0	rs767855853
2-223436603-C-A	ENST00000281828	p.Gly586Val	Missense Variant	2	31370	0.000064	rs141988189
2-223436607-C-T	ENST00000281828	p.Val585Ile	Missense Variant	25995	31278	0.831095	rs7185
2-223436610-T-C	ENST00000281828	p.Asn584Asp	Missense Variant	0	0	0	rs1179115421
2-223436613-T-C	ENST00000281828	p.Ile583Val	Missense Variant	0	0	0
2-223436616-C-G	ENST00000281828	p.Glu582Gln	Missense Variant	0	0	0	rs780568817
2-223436619-G-A	ENST00000281828	p.Leu581Leu	Synonymous Variant	0	0	0	rs748777302
2-223436629-G-C	ENST00000281828	p.Pro577Pro	Synonymous Variant	0	0	0	rs1398044215
2-223436634-T-G	ENST00000281828	p.Met576Leu	Missense Variant	1	31350	0.000032	rs1391411421
2-223436643-C-G	ENST00000281828	p.Glu573Gln	Missense Variant	0	0	0	rs778426408
2-223436658-C-T	ENST00000281828	p.Val568Ile	Missense Variant	1	31332	0.000032	rs747770664
2-223436659-G-A	ENST00000281828	p.Asp567Asp	Synonymous Variant	0	0	0	rs141929079
2-223436676-C-G	ENST00000281828	p.Gly562Arg	Missense Variant	1	31370	0.000032	rs267599217
2-223436683-C-T	ENST00000281828	p.Gly559Gly	Synonymous Variant	0	0	0	rs746834771
2-223436686-G-A	ENST00000281828	p.Val558Val	Synonymous Variant	0	0	0	rs770964019
2-223436688-C-T	ENST00000281828	p.Val558Ile	Missense Variant	0	0	0	rs776755911
2-223436689-G-A	ENST00000281828	p.Ser557Ser	Synonymous Variant	0	0	0	rs763107652

Showing 1 to 20 of 448 entries

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Post-translational Modifications (PTMs)

Acetylation

Methylation

Phosphorylation

Ubiquitination

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Gene Name	ACC ID	PTM Type	Position	Mod-rsd	Site +/-7 Aa	Mw_kd	Site grpID
FARSB	Q9NSD9	Ubiquitination	104	K104-ub	kRVMPDGkIQkLIIT	66.12	964514790
FARSB	Q9NSD9	Ubiquitination	107	K107-ub	MPDGkIQkLIITEET	66.12	964514792
FARSB	Q9NSD9	Acetylation	107	K107-ac	MPDGkIQkLIITEET	66.12	33348925
FARSB	Q9NSD9	Phosphorylation	136	Y136-p	IKFTKDRyDSFIELQ	66.12	23105804
FARSB	Q9NSD9	Ubiquitination	145	K145-ub	SFIELQEkLHQNICR	66.12	573787766
FARSB	Q9NSD9	Phosphorylation	161	T161-p	RALVAIGtHDLDTLs	66.12	23105801
FARSB	Q9NSD9	Phosphorylation	168	S168-p	tHDLDTLsGPFTYTA	66.12	23105695
FARSB	Q9NSD9	Ubiquitination	182	K182-ub	AKRPSDIkFKPLNKT	66.12	964514794
FARSB	Q9NSD9	Ubiquitination	190	K190-ub	FKPLNKTkEyTACEL	66.12	964514796
FARSB	Q9NSD9	Phosphorylation	192	Y192-p	PLNKTkEyTACELMN	66.12	457235
FARSB	Q9NSD9	Ubiquitination	202	K202-ub	CELMNIYkTDNHLKH	66.12	964514798
FARSB	Q9NSD9	Phosphorylation	226	S226-p	LYPVIYDsNGVVLSM	66.12	50778835
FARSB	Q9NSD9	Ubiquitination	262	K262-ub	CTGTDFTkAKIVLDI	66.12	964514800
FARSB	Q9NSD9	Ubiquitination	316	K316-ub	VRADLINkKVGIRET	66.12	964514802
FARSB	Q9NSD9	Ubiquitination	329	K329-ub	ETPENLAkLLTRMYL	66.12	22244448
FARSB	Q9NSD9	Acetylation	329	K329-ac	ETPENLAkLLTRMYL	66.12	11321154
FARSB	Q9NSD9	Ubiquitination	395	K395-ub	ANQFPLNkLTELLRH	66.12	15490946
FARSB	Q9NSD9	Ubiquitination	435	K435-ub	GVDISATkAVHISNP	66.12	964514804
FARSB	Q9NSD9	Ubiquitination	443	K443-ub	AVHISNPkTAEFQVA	66.12	27189335
FARSB	Q9NSD9	Phosphorylation	46	S46-p	TSEKEIIskEQGNVk	66.12	23105698

Showing 1 to 20 of 41 entries

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Catalogue of Somatic Mutations in Cancer (COSMIC)

Deletion - Frameshift

Insertion - Frameshift

Substitution - Coding Silent

Substitution - Missense

Substitution - Nonsense

Unknown

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Gene Name	Transcript ID	Sample name	Primary Site	Primary Histology	Mutation ID	Mutation CDS	Mutation Aa	Mutation Desc.	FATHMM Prediction	FATHMM Score	Mutation Somatic Status	PUBMED PMID	Tumor Origin	Position
FARSB	ENST00000281828	W10T	thyroid	carcinoma	26277124	c.1333G>A	p.A445T	Substitution - Missense	PATHOGENIC	.98635	Confirmed somatic variant	PMID: N/A	primary	445
FARSB	ENST00000281828	CPCG0240-F1	prostate	carcinoma	26275680	c.455+2519T>A	p.?	Unknown	NEUTRAL	.00369	Confirmed somatic variant	PMID: N/A	primary	0
FARSB	ENST00000281828	PCSI_0468_Pa_P_526	pancreas	carcinoma	26275288	c.1618+11671T>G	p.?	Unknown	NEUTRAL	.00292	Confirmed somatic variant	PMID: N/A	primary	0
FARSB	ENST00000281828	W10T	thyroid	carcinoma	26277120	c.1344G>T	p.Q448H	Substitution - Missense	PATHOGENIC	.9892	Confirmed somatic variant	PMID: N/A	primary	448
FARSB	ENST00000281828	PD13418a	breast	carcinoma	26274911	c.1618+8371C>A	p.?	Unknown	NEUTRAL	.00055	Confirmed somatic variant	PMID: N/A	NS	0
FARSB	ENST00000281828	T_CCA_SG_15	biliary_tract	carcinoma	26273613	c.1618+4003_1618+4006dup	p.?	Unknown			Confirmed somatic variant	PMID: N/A	primary	0
FARSB	ENST00000281828	PCSI_0010_Pa_X	pancreas	carcinoma	26278148	c.*711G>T	p.?	Unknown	NEUTRAL	.02591	Confirmed somatic variant	PMID: N/A	NS	0
FARSB	ENST00000281828	RK144_C01	liver	carcinoma	26275409	c.1345-1163A>C	p.?	Unknown	NEUTRAL	.03787	Confirmed somatic variant	PMID: N/A	NS	0
FARSB	ENST00000281828	GBM20-R3	central_nervous_system	glioma	26275200	c.61G>A	p.D21N	Substitution - Missense	PATHOGENIC	.97443	Confirmed somatic variant	PMID: 28263318	recurrent	21
FARSB	ENST00000281828	786-0	kidney	carcinoma	26275323	c.598A>C	p.I200L	Substitution - Missense	PATHOGENIC	.78524	Confirmed somatic variant	PMID: 23856246	primary	200
FARSB	ENST00000281828	TCGA-EE-A2MK-06	skin	malignant_melanoma	26276523	c.1258C>A	p.Q420K	Substitution - Missense	PATHOGENIC	.89766	Confirmed somatic variant	PMID: N/A	NS	420
FARSB	ENST00000281828	HCC20T	liver	carcinoma	26273719	c.-262A>C	p.?	Unknown	NEUTRAL	.01893	Reported in another cancer sample as somatic	PMID: N/A	primary	0
FARSB	ENST00000281828	TCGA-HU-8238-01	stomach	carcinoma	26275424	c.452G>T	p.C151F	Substitution - Missense	PATHOGENIC	.99306	Confirmed somatic variant	PMID: N/A	NS	151
FARSB	ENST00000281828	0076_CRUK_PC_0076_T1_DNA	prostate	carcinoma	26274345	c.115-621A>G	p.?	Unknown	NEUTRAL	.00268	Confirmed somatic variant	PMID: N/A	primary	0
FARSB	ENST00000281828	60T	liver	other	26276111	c.115-426G>A	p.?	Unknown	NEUTRAL	.0498	Confirmed somatic variant	PMID: N/A	primary	0
FARSB	ENST00000281828	LP6008221-DNA_B02	oesophagus	carcinoma	26275869	c.1619-3212C>G	p.?	Unknown	NEUTRAL	.01918	Confirmed somatic variant	PMID: N/A	primary	0
FARSB	ENST00000281828	CPCG0509-F1	prostate	carcinoma	26273750	c.456-689C>G	p.?	Unknown	NEUTRAL	.04218	Confirmed somatic variant	PMID: N/A	primary	0
FARSB	ENST00000281828	RK079_C01	liver	carcinoma	26278016	c.1618+13785G>A	p.?	Unknown	NEUTRAL	.00185	Variant of unknown origin	PMID: N/A	primary	0
FARSB	ENST00000281828	PD6415a	breast	carcinoma	26276434	c.1619-11498T>C	p.?	Unknown	NEUTRAL	.00445	Confirmed somatic variant	PMID: N/A	primary	0
FARSB	ENST00000281828	PD24336a	breast	carcinoma	26274931	c.1619-7824_1619-7822del	p.?	Unknown			Confirmed somatic variant	PMID: N/A	NS	0

Showing 1 to 20 of 253 entries

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dbSNP

Gene ID	Transcript ID	Consequence	Position	HGVSp	Impact

Protein Domains (PFAM)

Pfam Domain	Domain Name	Description	Positions	Clan	Clan Name	Organism
NO RESULT FOUND
PF03483	B3_4	B3/4 domain	117-279	CL0383	PheT-TilS	Homo sapiens
PF03484	B5	tRNA synthetase B5 domain	308-374	CL0123	HTH	Homo sapiens
PF17759	tRNA_synthFbeta	Phenylalanyl tRNA synthetase beta chain CLM domain	377-585	CL0040	tRNA_synt_II	Homo sapiens
PF18262	PhetRS_B1	Phe-tRNA synthetase beta subunit B1 domain	1-90			Homo sapiens

List of the diseases from DisGeNET

Disease Name	Disease Category	DSI*	DPI**
NO RESULT FOUND
NO RESULT FOUND

Description:	phenylalanyl-tRNA synthetase subunit beta [Source:HGNC Symbol;Acc:HGNC:17800]
Synonyms:	PheHB, FARSLB, HSPC173, PheRS, FRSB
Other ID(s):	HGNC:17800, ENSG00000116120
Protein Accession Numbers:	ENST00000281828.6, NP_005678, ENST00000281828, ENST00000536361
Statistics:	ClinVar(12) gnomAD(448) COSMIC(253) PTM(41)

Classification of Clinicial Significance of ClinVar Data