Chrna7 (GeneID: 11441) | Mus musculus
Description: cholinergic receptor, nicotinic, alpha polypeptide 7 [Source:MGI Symbol;Acc:MGI:99779]
Synonyms: Acra7, nAchR, alpha7
Other ID(s): ENSMUSG00000030525, MGI:99779
Protein Accession Numbers: NP_031416
Statistics: ClinVar(19) gnomAD(543) COSMIC(507) PTM(8)
ClinVar Pathogenicity of Variations help

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000306901 ENST00000437966 ENST00000454250 You are here now! ENST00000455693 NP_000737 NP_001177384 You are here now!


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF02931 Neur_chan_LBD Neurotransmitter-gated ion-channel ligand binding domain 26-230 Homo sapiens
PF02932 Neur_chan_memb Neurotransmitter-gated ion-channel transmembrane region 237-487 Homo sapiens

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Alzheimer's Disease Nervous System Diseases ; Mental Disorders ; 0.55 0.552
Auditory Perceptual Disorders Otorhinolaryngologic Diseases ; Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; Mental Disorders ; 0.55 0.552
Autistic Disorder Mental Disorders ; 0.55 0.552
Bipolar Disorder Mental Disorders ; 0.55 0.552
Presenile dementia Nervous System Diseases ; Mental Disorders ; 0.55 0.552
Epilepsy, Generalized Nervous System Diseases ; 0.55 0.552
Generalized Nonconvulsive Seizure Disorder Nervous System Diseases ; 0.55 0.552
Jacksonian Seizure Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Lung Neoplasms Neoplasms ; Respiratory Tract Diseases ; 0.55 0.552
Memory Disorders Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.55 0.552
Neoplasm Invasiveness Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Nerve Degeneration Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Nicotine Dependence Chemically-Induced Disorders ; Mental Disorders ; 0.55 0.552
Schizophrenia Mental Disorders ; 0.55 0.552
Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Spina Bifida Cystica Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.55 0.552
Substance Withdrawal Syndrome Chemically-Induced Disorders ; Mental Disorders ; 0.55 0.552
Sudden infant death syndrome Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Tobacco Dependence Chemically-Induced Disorders ; Mental Disorders ; 0.55 0.552
Tobacco Use Disorder Chemically-Induced Disorders ; Mental Disorders ; 0.55 0.552
Injuries, Acute Brain Nervous System Diseases ; Wounds and Injuries ; 0.55 0.552
Drug Withdrawal Symptoms Chemically-Induced Disorders ; Mental Disorders ; 0.55 0.552
Epilepsy, Atonic Nervous System Diseases ; 0.55 0.552
Epilepsy, Tonic Nervous System Diseases ; 0.55 0.552
Withdrawal Symptoms Chemically-Induced Disorders ; Mental Disorders ; 0.55 0.552
Complex partial seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Memory impairment Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.55 0.552
Generalized seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Seizures, Clonic Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Malignant neoplasm of lung Neoplasms ; Respiratory Tract Diseases ; 0.55 0.552
Brain Injuries Nervous System Diseases ; Wounds and Injuries ; 0.55 0.552
Visual seizure Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Tonic Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Epileptic drop attack Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Symptomatic Generalized Epilepsy Nervous System Diseases ; 0.55 0.552
Brain Lacerations Nervous System Diseases ; Wounds and Injuries ; 0.55 0.552
Familial Alzheimer Disease (FAD) Nervous System Diseases ; Mental Disorders ; 0.55 0.552
Generalized convulsive epilepsy Nervous System Diseases ; 0.55 0.552
Epilepsy, Akinetic Nervous System Diseases ; 0.55 0.552
Nicotine Use Disorder Chemically-Induced Disorders ; Mental Disorders ; 0.55 0.552
Seizures, Somatosensory Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Seizures, Auditory Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Olfactory seizure Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Gustatory seizure Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Vertiginous seizure Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Brain Injuries, Focal Nervous System Diseases ; Wounds and Injuries ; 0.55 0.552
Alzheimer Disease, Late Onset Nervous System Diseases ; Mental Disorders ; 0.55 0.552
Tonic - clonic seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Neurobehavioral Manifestations Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.55 0.552
Acute Confusional Senile Dementia Nervous System Diseases ; Mental Disorders ; 0.55 0.552
Alzheimer's Disease, Focal Onset Nervous System Diseases ; Mental Disorders ; 0.55 0.552
Alzheimer Disease, Early Onset Nervous System Diseases ; Mental Disorders ; 0.55 0.552
Auditory Inattention Otorhinolaryngologic Diseases ; Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; Mental Disorders ; 0.55 0.552
Non-epileptic convulsion Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Single Seizure Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Atonic Absence Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Age-Related Memory Disorders Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.55 0.552
Memory Disorder, Semantic Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.55 0.552
Memory Disorder, Spatial Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.55 0.552
Memory Loss Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; 0.55 0.552
Convulsive Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Seizures, Focal Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Seizures, Sensory Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Congenital omphalocele Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Spina Bifida, Open Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.55 0.552
Congenital exomphalos Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Chromosome 15q13.3 Microdeletion Syndrome Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; Mental Disorders ; 0.55 0.552
Nonepileptic Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Convulsions Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Absence Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Epileptic Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Myoclonic Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
Generalized Absence Seizures Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.55 0.552
NO RESULT FOUND
feedback