gsk3b (GeneID: 30654) | Danio rerio
Description: glycogen synthase kinase 3 beta [Source:ZFIN;Acc:ZDB-GENE-990714-4]
Synonyms: wu:fb68h05, GSK3, fb68h05, u:fk80d11, GSK-3[b], wu:fk80d11, u:fb68h05, fk80d11
Other ID(s): ENSDARG00000017803, ZDB-GENE-990714-4
Protein Accession Numbers: XP_009302769, NP_571456
Statistics: ClinVar(5) gnomAD(227) COSMIC(657) PTM(43)
ClinVar Pathogenicity of Variations help

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000264235 You are here now! ENST00000316626 NP_001139628 You are here now! NP_002084


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00069 Pkinase Protein kinase domain 56-340 CL0016 PKinase Homo sapiens

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Multiple congenital anomalies Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.488 0.793
Alzheimer's Disease Nervous System Diseases ; Mental Disorders ; 0.488 0.793
Arthritis, Adjuvant-Induced Musculoskeletal Diseases ; 0.488 0.793
Bipolar Disorder Mental Disorders ; 0.488 0.793
Depression, Bipolar Mental Disorders ; 0.488 0.793
Cognition Disorders Mental Disorders ; 0.488 0.793
Presenile dementia Nervous System Diseases ; Mental Disorders ; 0.488 0.793
Mental Depression Behavior and Behavior Mechanisms ; 0.488 0.793
Endogenous depression Mental Disorders ; 0.488 0.793
Depressive disorder Mental Disorders ; 0.488 0.793
Cardiomegaly Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.488 0.793
Heart failure Cardiovascular Diseases ; 0.488 0.793
Congestive heart failure Cardiovascular Diseases ; 0.488 0.793
Hypertensive disease Cardiovascular Diseases ; 0.488 0.793
Kidney Failure, Acute Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.488 0.793
Left-Sided Heart Failure Cardiovascular Diseases ; 0.488 0.793
Manic Disorder Mental Disorders ; 0.488 0.793
Melancholia Mental Disorders ; 0.488 0.793
Muscular Atrophy Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.488 0.793
Myocardial Infarction Cardiovascular Diseases ; 0.488 0.793
Peritonitis Bacterial Infections and Mycoses ; Digestive System Diseases ; 0.488 0.793
Poisoning Chemically-Induced Disorders ; 0.488 0.793
Prostatic Neoplasms Neoplasms ; Male Urogenital Diseases ; 0.488 0.793
Schizophrenia Mental Disorders ; 0.488 0.793
Unipolar Depression Mental Disorders ; 0.488 0.793
Injuries, Acute Brain Nervous System Diseases ; Wounds and Injuries ; 0.488 0.793
Depressive Syndrome Mental Disorders ; 0.488 0.793
Heart Failure, Right-Sided Cardiovascular Diseases ; 0.488 0.793
Brain Injuries Nervous System Diseases ; Wounds and Injuries ; 0.488 0.793
Neurogenic Muscular Atrophy Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.488 0.793
Brain Lacerations Nervous System Diseases ; Wounds and Injuries ; 0.488 0.793
Familial Alzheimer Disease (FAD) Nervous System Diseases ; Mental Disorders ; 0.488 0.793
Depression, Neurotic Mental Disorders ; 0.488 0.793
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.488 0.793
Manic Mental Disorders ; 0.488 0.793
Malignant neoplasm of prostate Neoplasms ; Male Urogenital Diseases ; 0.488 0.793
Brain Injuries, Focal Nervous System Diseases ; Wounds and Injuries ; 0.488 0.793
Alzheimer Disease, Late Onset Nervous System Diseases ; Mental Disorders ; 0.488 0.793
Mood Disorders Mental Disorders ; 0.488 0.793
Acute Confusional Senile Dementia Nervous System Diseases ; Mental Disorders ; 0.488 0.793
Alzheimer's Disease, Focal Onset Nervous System Diseases ; Mental Disorders ; 0.488 0.793
Alzheimer Disease, Early Onset Nervous System Diseases ; Mental Disorders ; 0.488 0.793
Lymphoma, Lymphocytic, Intermediate Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.488 0.793
Tauopathies Nervous System Diseases ; 0.488 0.793
Arthritis, Collagen-Induced Musculoskeletal Diseases ; 0.488 0.793
Arthritis, Experimental Musculoskeletal Diseases ; 0.488 0.793
Major Depressive Disorder Mental Disorders ; 0.488 0.793
Cardiac Hypertrophy Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.488 0.793
Primary Peritonitis Bacterial Infections and Mycoses ; Digestive System Diseases ; 0.488 0.793
Secondary Peritonitis Bacterial Infections and Mycoses ; Digestive System Diseases ; 0.488 0.793
Acute Kidney Insufficiency Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.488 0.793
CEROID LIPOFUSCINOSIS, NEURONAL, 6 Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Nutritional and Metabolic Diseases ; 0.488 0.793
Myocardial Failure Cardiovascular Diseases ; 0.488 0.793
Heart Decompensation Cardiovascular Diseases ; 0.488 0.793
Acute kidney injury Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.488 0.793
NO RESULT FOUND
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