TRIO (GeneID: 717492) | Macaca mulatta
Description: trio Rho guanine nucleotide exchange factor [Source:NCBI gene;Acc:717492]
Synonyms:
Other ID(s): ENSMMUG00000015489
Protein Accession Numbers: XP_014995236, XP_014995235
Statistics: ClinVar(303) COSMIC(1556) PTM(83)
ClinVar Pathogenicity of Variations help

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000344135 ENST00000344204 You are here now! ENST00000509967 ENST00000512070 ENST00000513206 ENST00000537187 NP_009049 You are here now!


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00018 SH3_1 SH3 domain 1662-1713 CL0010 SH3 Homo sapiens
PF00169 PH PH domain 1480-1591 CL0266 PH Homo sapiens
PF00169 PH PH domain 2159-2271 CL0266 PH Homo sapiens
PF00435 Spectrin Spectrin repeat 340-446 Homo sapiens
PF00435 Spectrin Spectrin repeat 1138-1244 Homo sapiens
PF00435 Spectrin Spectrin repeat 907-1011 Homo sapiens
PF00435 Spectrin Spectrin repeat 566-672 Homo sapiens
PF00621 RhoGEF RhoGEF domain 1973-2143 Homo sapiens
PF00621 RhoGEF RhoGEF domain 1296-1468 Homo sapiens
PF00650 CRAL_TRIO CRAL/TRIO domain 70-204 CL0512 CRAL_TRIO Homo sapiens
PF16609 SH3-RhoG_link SH3-RhoGEF linking unstructured region 1715-1972 Homo sapiens
PF07679 I-set Immunoglobulin I-set domain 2685-2776 CL0011 Ig Homo sapiens
PF00069 Pkinase Protein kinase domain 2796-3050 CL0016 PKinase Homo sapiens

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Leukemia, Myelocytic, Acute Neoplasms ; 0.636 0.517
Liver neoplasms Neoplasms ; Digestive System Diseases ; 0.636 0.517
Acute Myeloid Leukemia, M1 Neoplasms ; 0.636 0.517
Precancerous Conditions Neoplasms ; 0.636 0.517
Metastatic melanoma N/A 0.636 0.517
Condition, Preneoplastic Neoplasms ; 0.636 0.517
Malignant neoplasm of liver Neoplasms ; Digestive System Diseases ; 0.636 0.517
Neurodevelopmental Disorders Mental Disorders ; 0.636 0.517
Acute Myeloid Leukemia (AML-M2) Neoplasms ; 0.636 0.517
MENTAL RETARDATION, AUTOSOMAL DOMINANT 44 N/A 0.636 0.517
NO RESULT FOUND
feedback