CASP3 (GeneID: 461669) | Pan troglodytes
Description: caspase 3 [Source:VGNC Symbol;Acc:VGNC:2081]
Synonyms:
Other ID(s): ENSPTRG00000016640
Protein Accession Numbers: XP_016806492, XP_009446812, XP_016806491, XP_009446811, XP_016806493, XP_009446814, NP_001012435
Statistics: ClinVar(9) gnomAD(340) COSMIC(211) PTM(26)
ClinVar Pathogenicity of Variations help

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000308394 You are here now! ENST00000393585 ENST00000393588 ENST00000447121 ENST00000517513 ENST00000523916 You are here now! NP_001341706 You are here now! NP_001341708 NP_001341709 NP_001341710 NP_001341711 NP_001341712 NP_001341713 NP_004337 You are here now! NP_116786 You are here now!


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00656 Peptidase_C14 Caspase domain 44-274 CL0093 Peptidase_CD Homo sapiens

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Alloxan Diabetes Nutritional and Metabolic Diseases ; Endocrine System Diseases ; 0.391 0.862
Alzheimer's Disease Nervous System Diseases ; Mental Disorders ; 0.391 0.862
Calcinosis Nutritional and Metabolic Diseases ; 0.391 0.862
Brain Ischemia Nervous System Diseases ; Cardiovascular Diseases ; 0.391 0.862
Ulcerative Colitis Digestive System Diseases ; 0.391 0.862
Cryptorchidism Male Urogenital Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Endocrine System Diseases ; 0.391 0.862
Presenile dementia Nervous System Diseases ; Mental Disorders ; 0.391 0.862
Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases ; Endocrine System Diseases ; 0.391 0.862
Diabetes Mellitus, Non-Insulin-Dependent Nutritional and Metabolic Diseases ; Endocrine System Diseases ; 0.391 0.862
Diabetic Angiopathies Cardiovascular Diseases ; Endocrine System Diseases ; 0.391 0.862
Diabetic Neuropathies Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Diabetic Retinopathy Eye Diseases ; Cardiovascular Diseases ; Endocrine System Diseases ; 0.391 0.862
Edema Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Eperythrozoonosis Bacterial Infections and Mycoses ; 0.391 0.862
Heart valve disease Cardiovascular Diseases ; 0.391 0.862
Hepatitis, Chronic Digestive System Diseases ; 0.391 0.862
Microangiopathy, Diabetic Cardiovascular Diseases ; Endocrine System Diseases ; 0.391 0.862
Mycoplasma Infections Bacterial Infections and Mycoses ; 0.391 0.862
Myocardial Infarction Cardiovascular Diseases ; 0.391 0.862
Myocardial Reperfusion Injury Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Nerve Degeneration Pathological Conditions, Signs and Symptoms ; 0.391 0.862
nervous system disorder Nervous System Diseases ; 0.391 0.862
Pyemia Bacterial Infections and Mycoses ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Reperfusion Injury Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Retinal Detachment Eye Diseases ; 0.391 0.862
Schizophrenia Mental Disorders ; 0.391 0.862
Septicemia Bacterial Infections and Mycoses ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Spinal Cord Injuries Nervous System Diseases ; Wounds and Injuries ; 0.391 0.862
Status Epilepticus Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Streptozotocin Diabetes Nutritional and Metabolic Diseases ; Endocrine System Diseases ; 0.391 0.862
Subarachnoid Hemorrhage Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Encephalopathy, Toxic Nervous System Diseases ; Chemically-Induced Disorders ; 0.391 0.862
Chronic Persistent Hepatitis Digestive System Diseases ; 0.391 0.862
Anasarca Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Toxic Encephalitis Nervous System Diseases ; Chemically-Induced Disorders ; 0.391 0.862
Neurotoxicity Syndromes Nervous System Diseases ; Chemically-Induced Disorders ; 0.391 0.862
Sepsis Bacterial Infections and Mycoses ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Tumoral calcinosis Nutritional and Metabolic Diseases ; 0.391 0.862
Perinatal Subarachnoid Hemorrhage Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Petit mal status Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Symmetric Diabetic Proximal Motor Neuropathy Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Asymmetric Diabetic Proximal Motor Neuropathy Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Diabetic Mononeuropathy Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Diabetic Polyneuropathies Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Diabetic Amyotrophy Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Diabetic Autonomic Neuropathy Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Familial Alzheimer Disease (FAD) Nervous System Diseases ; Mental Disorders ; 0.391 0.862
Grand Mal Status Epilepticus Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Retinal Pigment Epithelial Detachment Eye Diseases ; 0.391 0.862
Complex Partial Status Epilepticus Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Diabetic Asymmetric Polyneuropathy Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Bilateral Cryptorchidism Male Urogenital Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Endocrine System Diseases ; 0.391 0.862
Unilateral Cryptorchidism Male Urogenital Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Endocrine System Diseases ; 0.391 0.862
Spinal Cord Contusion Nervous System Diseases ; Wounds and Injuries ; 0.391 0.862
Spinal Cord Laceration Nervous System Diseases ; Wounds and Injuries ; 0.391 0.862
Spinal Cord transection injury Nervous System Diseases ; Wounds and Injuries ; 0.391 0.862
Subarachnoid Hemorrhage, Spontaneous Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Alzheimer Disease, Late Onset Nervous System Diseases ; Mental Disorders ; 0.391 0.862
Chronic active hepatitis Digestive System Diseases ; 0.391 0.862
Microcalcification Nutritional and Metabolic Diseases ; 0.391 0.862
Cryptogenic Chronic Hepatitis Digestive System Diseases ; 0.391 0.862
Acute Confusional Senile Dementia Nervous System Diseases ; Mental Disorders ; 0.391 0.862
Alzheimer's Disease, Focal Onset Nervous System Diseases ; Mental Disorders ; 0.391 0.862
Alzheimer Disease, Early Onset Nervous System Diseases ; Mental Disorders ; 0.391 0.862
Diabetic Neuralgia Nervous System Diseases ; Endocrine System Diseases ; 0.391 0.862
Post-Traumatic Myelopathy Nervous System Diseases ; Wounds and Injuries ; 0.391 0.862
Status Epilepticus, Subclinical Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Non-Convulsive Status Epilepticus Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Simple Partial Status Epilepticus Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Subarachnoid Hemorrhage, Aneurysmal Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Subarachnoid Hemorrhage, Intracranial Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Cerebral Ischemia Nervous System Diseases ; Cardiovascular Diseases ; 0.391 0.862
Abdominal Cryptorchidism Male Urogenital Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Endocrine System Diseases ; 0.391 0.862
Inguinal Cryptorchidism Male Urogenital Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Endocrine System Diseases ; 0.391 0.862
Severe Sepsis Bacterial Infections and Mycoses ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Copper-Overload Cirrhosis Digestive System Diseases ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Nutritional and Metabolic Diseases ; 0.391 0.862
Cerebral Hemorrhage Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.391 0.862
Familial Ménière disease N/A 0.391 0.862
NO RESULT FOUND
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