SPARC (GeneID: 6678) | Homo sapiens
Description: secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219]
Synonyms: BM-40, ON, OI17
Other ID(s): ENSG00000113140, HGNC:11219
Protein Accession Numbers: ENST00000521569, NP_001296373, ENST00000538026, ENST00000231061, NP_001296372, ENST00000522348, NP_003109, ENST00000539687
Statistics: ClinVar(21) gnomAD(254) COSMIC(190) PTM(2)
ClinVar Pathogenicity of Variations help

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000231061 You are here now! ENST00000521569 ENST00000522348 ENST00000538026 ENST00000539687 NP_001296372 NP_001296373 NP_003109 You are here now!


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00050 Kazal_1 Kazal-type serine protease inhibitor domain 95-149 CL0005 Kazal Homo sapiens
PF09289 FOLN Follistatin/Osteonectin-like EGF domain 72-93 CL0001 EGF Homo sapiens
PF10591 SPARC_Ca_bdg Secreted protein acidic and rich in cysteine Ca binding region 152-289 CL0220 EF_hand Homo sapiens

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Malignant tumor of colon Neoplasms ; Digestive System Diseases ; 0.466 0.793
Colonic Neoplasms Neoplasms ; Digestive System Diseases ; 0.466 0.793
Colorectal Carcinoma Neoplasms ; Digestive System Diseases ; 0.466 0.793
Colorectal Neoplasms Neoplasms ; Digestive System Diseases ; 0.466 0.793
Hepatitis Digestive System Diseases ; 0.466 0.793
Hyperalgesia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Kidney Diseases Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.466 0.793
Leukemia, Myelocytic, Acute Neoplasms ; 0.466 0.793
Liver Cirrhosis Digestive System Diseases ; 0.466 0.793
Liver Cirrhosis, Experimental Digestive System Diseases ; 0.466 0.793
Lobstein Disease Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.466 0.793
Low Back Pain Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Multiple Myeloma Neoplasms ; Cardiovascular Diseases ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.466 0.793
Acute Myeloid Leukemia, M1 Neoplasms ; 0.466 0.793
Necrosis Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Neoplasms, Experimental Neoplasms ; 0.466 0.793
Osteogenesis Imperfecta Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.466 0.793
Thrombocytopenia Hemic and Lymphatic Diseases ; 0.466 0.793
Uremia Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.466 0.793
Weight Gain Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Myocardial Ischemia Cardiovascular Diseases ; 0.466 0.793
Intervertebral Disc Degeneration Musculoskeletal Diseases ; 0.466 0.793
Adrenocortical carcinoma Neoplasms ; Endocrine System Diseases ; 0.466 0.793
Fibrosis, Liver Digestive System Diseases ; 0.466 0.793
Osteogenesis imperfecta type IV (disorder) Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.466 0.793
Low Back Pain, Mechanical Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Low Back Pain, Posterior Compartment Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Low Back Pain, Postural Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Hyperalgesia, Primary Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Hyperalgesia, Secondary Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Tactile Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Hyperalgesia, Thermal Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Recurrent Low Back Pain Pathological Conditions, Signs and Symptoms ; 0.466 0.793
ovarian neoplasm Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.466 0.793
Malignant neoplasm of ovary Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.466 0.793
Colorectal Cancer Neoplasms ; Digestive System Diseases ; 0.466 0.793
Acute Myeloid Leukemia (AML-M2) Neoplasms ; 0.466 0.793
Degenerative Intervertebral Discs Musculoskeletal Diseases ; 0.466 0.793
Mechanical Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
OSTEOGENESIS IMPERFECTA, TYPE XVII N/A 0.466 0.793
NO RESULT FOUND
feedback