SPARC (GeneID: 6678) | Homo sapiens
Description: secreted protein acidic and cysteine rich [Source:HGNC Symbol;Acc:HGNC:11219]
Synonyms: BM-40, ON, OI17
Other ID(s): ENSG00000113140, HGNC:11219
Protein Accession Numbers: ENST00000521569, NP_001296373, ENST00000538026, ENST00000231061, NP_001296372, ENST00000522348, NP_003109, ENST00000539687
Statistics: gnomAD(38)
gnomAD Variants By Annotation

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000231061 ENST00000521569 ENST00000522348 ENST00000538026 ENST00000539687 NP_001296372 NP_001296373 NP_003109


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF07648 Kazal_2 Kazal-type serine protease inhibitor domain 1-48 CL0005 Kazal Caenorhabditis elegans
PF10591 SPARC_Ca_bdg Secreted protein acidic and rich in cysteine Ca binding region 51-165 CL0220 EF_hand Caenorhabditis elegans

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Malignant tumor of colon Neoplasms ; Digestive System Diseases ; 0.466 0.793
Colonic Neoplasms Neoplasms ; Digestive System Diseases ; 0.466 0.793
Colorectal Carcinoma Neoplasms ; Digestive System Diseases ; 0.466 0.793
Colorectal Neoplasms Neoplasms ; Digestive System Diseases ; 0.466 0.793
Hepatitis Digestive System Diseases ; 0.466 0.793
Hyperalgesia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Kidney Diseases Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.466 0.793
Leukemia, Myelocytic, Acute Neoplasms ; 0.466 0.793
Liver Cirrhosis Digestive System Diseases ; 0.466 0.793
Liver Cirrhosis, Experimental Digestive System Diseases ; 0.466 0.793
Lobstein Disease Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.466 0.793
Low Back Pain Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Multiple Myeloma Neoplasms ; Cardiovascular Diseases ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.466 0.793
Acute Myeloid Leukemia, M1 Neoplasms ; 0.466 0.793
Necrosis Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Neoplasms, Experimental Neoplasms ; 0.466 0.793
Osteogenesis Imperfecta Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.466 0.793
Thrombocytopenia Hemic and Lymphatic Diseases ; 0.466 0.793
Uremia Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.466 0.793
Weight Gain Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Myocardial Ischemia Cardiovascular Diseases ; 0.466 0.793
Intervertebral Disc Degeneration Musculoskeletal Diseases ; 0.466 0.793
Adrenocortical carcinoma Neoplasms ; Endocrine System Diseases ; 0.466 0.793
Fibrosis, Liver Digestive System Diseases ; 0.466 0.793
Osteogenesis imperfecta type IV (disorder) Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.466 0.793
Low Back Pain, Mechanical Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Low Back Pain, Posterior Compartment Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Low Back Pain, Postural Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Hyperalgesia, Primary Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Hyperalgesia, Secondary Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Tactile Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Hyperalgesia, Thermal Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Recurrent Low Back Pain Pathological Conditions, Signs and Symptoms ; 0.466 0.793
ovarian neoplasm Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.466 0.793
Malignant neoplasm of ovary Neoplasms ; Female Urogenital Diseases and Pregnancy Complications ; Endocrine System Diseases ; 0.466 0.793
Colorectal Cancer Neoplasms ; Digestive System Diseases ; 0.466 0.793
Acute Myeloid Leukemia (AML-M2) Neoplasms ; 0.466 0.793
Degenerative Intervertebral Discs Musculoskeletal Diseases ; 0.466 0.793
Mechanical Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
OSTEOGENESIS IMPERFECTA, TYPE XVII N/A 0.466 0.793
NO RESULT FOUND
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