TREM2 (GeneID: 54209) | Homo sapiens
Description: triggering receptor expressed on myeloid cells 2 [Source:HGNC Symbol;Acc:HGNC:17761]
Synonyms: Trem2c, TREM-2, Trem2b, Trem2a
Other ID(s): HGNC:17761, ENSG00000095970
Protein Accession Numbers: ENST00000338469, NP_061838, ENST00000373113.3, NP_001258750, ENST00000373113, ENST00000373122
Statistics: gnomAD(216) COSMIC(79) PTM(2)
Post translational modifications (PTM) by Type

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000338469 ENST00000373113 ENST00000373122 NP_001258750 NP_061838


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF07686 V-set Immunoglobulin V-set domain 20-129 CL0011 Ig Mus musculus

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Alzheimer's Disease Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Amyotrophic Lateral Sclerosis Nervous System Diseases ; Nutritional and Metabolic Diseases ; 0.572 0.552
Presenile dementia Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Osteogenesis Imperfecta Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.572 0.552
Familial Alzheimer Disease (FAD) Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Semantic Dementia Nervous System Diseases ; Nutritional and Metabolic Diseases ; Mental Disorders ; 0.572 0.552
Senile Paranoid Dementia Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Alzheimer Disease, Late Onset Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Dementia Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Acute Confusional Senile Dementia Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Alzheimer's Disease, Focal Onset Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Alzheimer Disease, Early Onset Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Familial Dementia Nervous System Diseases ; Mental Disorders ; 0.572 0.552
Primary Progressive Nonfluent Aphasia Nervous System Diseases ; Nutritional and Metabolic Diseases ; Pathological Conditions, Signs and Symptoms ; Mental Disorders ; 0.572 0.552
POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY Virus Diseases ; Musculoskeletal Diseases ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; Nutritional and Metabolic Diseases ; 0.572 0.552
Behavioral variant of frontotemporal dementia N/A 0.572 0.552
NO RESULT FOUND
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