IGF1 (GeneID: 3479) | Homo sapiens
Description: insulin like growth factor 1 [Source:HGNC Symbol;Acc:HGNC:5464]
Synonyms: IGF-I, MGF, IGFI
Other ID(s): ENSG00000017427, HGNC:5464
Protein Accession Numbers: ENST00000307046.8, NP_001104754, ENST00000456098, ENST00000392904, ENST00000307046, NP_001104753, ENST00000424202, ENST00000337514, NP_001104755, NP_000609, ENST00000392905
Statistics: gnomAD(111) PTM(3)
Post translational modifications (PTM) by Type

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000307046 ENST00000337514 ENST00000392904 ENST00000392905 ENST00000424202 ENST00000456098 NP_000609 NP_001104753 NP_001104754 NP_001104755


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00049 Insulin Insulin/IGF/Relaxin family 61-93 CL0239 Insulin Mus musculus
PF00049 Insulin Insulin/IGF/Relaxin family 35-70 CL0239 Insulin Mus musculus

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Spontaneous abortion Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Abortion, Tubal Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Acromegaly Musculoskeletal Diseases ; Nervous System Diseases ; Endocrine System Diseases ; 0.355 0.828
Adenoma Neoplasms ; 0.355 0.828
Alloxan Diabetes Nutritional and Metabolic Diseases ; Endocrine System Diseases ; 0.355 0.828
Alzheimer's Disease Nervous System Diseases ; Mental Disorders ; 0.355 0.828
Autistic Disorder Mental Disorders ; 0.355 0.828
Bipolar Disorder Mental Disorders ; 0.355 0.828
Malignant neoplasm of urinary bladder Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Bladder Neoplasm Neoplasms ; Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Metabolic Bone Disorder Musculoskeletal Diseases ; Nutritional and Metabolic Diseases ; 0.355 0.828
Malignant neoplasm of breast Neoplasms ; Skin and Connective Tissue Diseases ; 0.355 0.828
Malignant neoplasm of skin Neoplasms ; Skin and Connective Tissue Diseases ; 0.355 0.828
Cholestasis Digestive System Diseases ; 0.355 0.828
Colitis Digestive System Diseases ; 0.355 0.828
Corneal Diseases Eye Diseases ; 0.355 0.828
Crohn Disease Digestive System Diseases ; 0.355 0.828
Delirium Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; Mental Disorders ; 0.355 0.828
Presenile dementia Nervous System Diseases ; Mental Disorders ; 0.355 0.828
Demyelinating Diseases Nervous System Diseases ; 0.355 0.828
Demyelination Nervous System Diseases ; 0.355 0.828
Mental Depression Behavior and Behavior Mechanisms ; 0.355 0.828
Depressive disorder Mental Disorders ; 0.355 0.828
Diabetes Mellitus, Experimental Nutritional and Metabolic Diseases ; Endocrine System Diseases ; 0.355 0.828
Diabetes Mellitus, Insulin-Dependent Nutritional and Metabolic Diseases ; Endocrine System Diseases ; Immune System Diseases ; 0.355 0.828
Drug toxicity Chemically-Induced Disorders ; 0.355 0.828
Endometriosis Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Cardiomegaly Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Hepatitis, Toxic Digestive System Diseases ; Chemically-Induced Disorders ; 0.355 0.828
Diaphragmatic Hernia Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Hyperalgesia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Hypertensive disease Cardiovascular Diseases ; 0.355 0.828
Kidney Diseases Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Kidney Failure, Acute Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Kidney Failure, Chronic Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Liver Cirrhosis, Experimental Digestive System Diseases ; 0.355 0.828
Mammary Neoplasms, Experimental Neoplasms ; 0.355 0.828
Muscular Atrophy Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Neoplasm Invasiveness Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Neoplasm Metastasis Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Nerve Degeneration Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Osteogenesis Imperfecta Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Skin and Connective Tissue Diseases ; 0.355 0.828
Osteopenia Musculoskeletal Diseases ; Nutritional and Metabolic Diseases ; 0.355 0.828
Peripheral Neuropathy Nervous System Diseases ; 0.355 0.828
Pituitary Adenoma Neoplasms ; Nervous System Diseases ; Endocrine System Diseases ; 0.355 0.828
Pituitary Neoplasms Neoplasms ; Nervous System Diseases ; Endocrine System Diseases ; 0.355 0.828
Prostatic Neoplasms Neoplasms ; Male Urogenital Diseases ; 0.355 0.828
Precocious Puberty Endocrine System Diseases ; 0.355 0.828
Pulmonary Fibrosis Respiratory Tract Diseases ; 0.355 0.828
Skin Neoplasms Neoplasms ; Skin and Connective Tissue Diseases ; 0.355 0.828
Streptozotocin Diabetes Nutritional and Metabolic Diseases ; Endocrine System Diseases ; 0.355 0.828
Adverse reaction to drug Chemically-Induced Disorders ; 0.355 0.828
Alcohol abuse Chemically-Induced Disorders ; Mental Disorders ; 0.355 0.828
Hamman-Rich syndrome Respiratory Tract Diseases ; 0.355 0.828
Myocardial Ischemia Cardiovascular Diseases ; 0.355 0.828
Crohn's disease of large bowel Digestive System Diseases ; 0.355 0.828
Russell-Silver syndrome Musculoskeletal Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.355 0.828
Adenoma, Basal Cell Neoplasms ; 0.355 0.828
Follicular adenoma Neoplasms ; 0.355 0.828
Adenoma, Microcystic Neoplasms ; 0.355 0.828
Adenoma, Monomorphic Neoplasms ; 0.355 0.828
Papillary adenoma Neoplasms ; 0.355 0.828
Adenoma, Trabecular Neoplasms ; 0.355 0.828
Diabetes, Autoimmune Nutritional and Metabolic Diseases ; Endocrine System Diseases ; Immune System Diseases ; 0.355 0.828
Middle Cerebral Artery Syndrome Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Crohn's disease of the ileum Digestive System Diseases ; 0.355 0.828
Endometrioma Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Neurogenic Muscular Atrophy Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Familial Alzheimer Disease (FAD) Nervous System Diseases ; Mental Disorders ; 0.355 0.828
Brittle diabetes Nutritional and Metabolic Diseases ; Endocrine System Diseases ; Immune System Diseases ; 0.355 0.828
Pituitary carcinoma Neoplasms ; Nervous System Diseases ; Endocrine System Diseases ; 0.355 0.828
Malignant neoplasm of prostate Neoplasms ; Male Urogenital Diseases ; 0.355 0.828
Primary microcephaly N/A 0.355 0.828
Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Alzheimer Disease, Late Onset Nervous System Diseases ; Mental Disorders ; 0.355 0.828
Acute Confusional Senile Dementia Nervous System Diseases ; Mental Disorders ; 0.355 0.828
Regional enteritis Digestive System Diseases ; 0.355 0.828
Breast Carcinoma Neoplasms ; Skin and Connective Tissue Diseases ; 0.355 0.828
Middle Cerebral Artery Thrombosis Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Middle Cerebral Artery Occlusion Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Alzheimer's Disease, Focal Onset Nervous System Diseases ; Mental Disorders ; 0.355 0.828
Alzheimer Disease, Early Onset Nervous System Diseases ; Mental Disorders ; 0.355 0.828
Hyperalgesia, Primary Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Hyperalgesia, Secondary Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Tactile Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Hyperalgesia, Thermal Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Middle Cerebral Artery Embolus Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Left Middle Cerebral Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Embolic Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Thrombotic Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Right Middle Cerebral Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.355 0.828
Diabetic Cardiomyopathies Cardiovascular Diseases ; Endocrine System Diseases ; 0.355 0.828
Drug-Induced Liver Disease Digestive System Diseases ; Chemically-Induced Disorders ; 0.355 0.828
IIeocolitis Digestive System Diseases ; 0.355 0.828
Mammary Neoplasms, Human Neoplasms ; Skin and Connective Tissue Diseases ; 0.355 0.828
Hepatitis, Drug-Induced Digestive System Diseases ; Chemically-Induced Disorders ; 0.355 0.828
Cardiac Hypertrophy Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Mammary Neoplasms Neoplasms ; Skin and Connective Tissue Diseases ; 0.355 0.828
Acute Kidney Insufficiency Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Insulin-Like Growth Factor I Deficiency Otorhinolaryngologic Diseases ; Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Clinically Isolated Syndrome, CNS Demyelinating Nervous System Diseases ; 0.355 0.828
Acute kidney injury Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.355 0.828
Mechanical Allodynia Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.355 0.828
Drug-Induced Acute Liver Injury Digestive System Diseases ; Chemically-Induced Disorders ; 0.355 0.828
Intellectual Disability Nervous System Diseases ; Pathological Conditions, Signs and Symptoms ; Behavior and Behavior Mechanisms ; Mental Disorders ; 0.355 0.828
Diabetes Mellitus, Ketosis-Prone Nutritional and Metabolic Diseases ; Endocrine System Diseases ; Immune System Diseases ; 0.355 0.828
Chemical and Drug Induced Liver Injury Digestive System Diseases ; Chemically-Induced Disorders ; 0.355 0.828
Chemically-Induced Liver Toxicity Digestive System Diseases ; Chemically-Induced Disorders ; 0.355 0.828
NO RESULT FOUND
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