F2 (GeneID: 2147) | Homo sapiens
Description: coagulation factor II, thrombin [Source:HGNC Symbol;Acc:HGNC:3535]
Synonyms: PT, THPH1, RPRGL2
Other ID(s): ENSG00000180210, HGNC:3535
Protein Accession Numbers: ENST00000311907.5, ENST00000530231, ENST00000311907, NP_001298186, ENST00000442468, NP_000497
Statistics: gnomAD(267)
gnomAD Variants By Annotation

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000311907 ENST00000442468 ENST00000530231 NP_000497 NP_001298186


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
NO DOMAINS EXIST

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Alzheimer's Disease Nervous System Diseases ; Mental Disorders ; 0.466 0.793
Rheumatoid Arthritis Musculoskeletal Diseases ; Skin and Connective Tissue Diseases ; Immune System Diseases ; 0.466 0.793
Blood Coagulation Disorders Hemic and Lymphatic Diseases ; 0.466 0.793
Cerebral Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Brain Ischemia Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Presenile dementia Nervous System Diseases ; Mental Disorders ; 0.466 0.793
Disseminated Intravascular Coagulation Hemic and Lymphatic Diseases ; 0.466 0.793
Fatty Liver Digestive System Diseases ; 0.466 0.793
Hemorrhage Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Hypertrophy Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Inherited Factor II deficiency Hemic and Lymphatic Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.466 0.793
Liver Cirrhosis Digestive System Diseases ; 0.466 0.793
Myocardial Infarction Cardiovascular Diseases ; 0.466 0.793
Nephrosis Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.466 0.793
Nerve Degeneration Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Obesity Nutritional and Metabolic Diseases ; Pathological Conditions, Signs and Symptoms ; 0.466 0.793
Paratuberculosis Bacterial Infections and Mycoses ; Animal Diseases ; 0.466 0.793
Schizophrenia Mental Disorders ; 0.466 0.793
Sinus Thrombosis, Intracranial Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Cerebrovascular accident Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Thromboembolism Cardiovascular Diseases ; 0.466 0.793
Thrombosis Cardiovascular Diseases ; 0.466 0.793
Venous Thrombosis Cardiovascular Diseases ; 0.466 0.793
Liver Failure Digestive System Diseases ; 0.466 0.793
Alcohol abuse Chemically-Induced Disorders ; Mental Disorders ; 0.466 0.793
Thrombus Cardiovascular Diseases ; 0.466 0.793
Deep Vein Thrombosis Cardiovascular Diseases ; 0.466 0.793
Skin Diseases, Vascular Skin and Connective Tissue Diseases ; 0.466 0.793
Fibrosis, Liver Digestive System Diseases ; 0.466 0.793
Mesenteric Venous Thrombosis Digestive System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Hereditary factor II deficiency disease Hemic and Lymphatic Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.466 0.793
Familial Alzheimer Disease (FAD) Nervous System Diseases ; Mental Disorders ; 0.466 0.793
Thrombophilia Hemic and Lymphatic Diseases ; 0.466 0.793
Non-alcoholic Fatty Liver Disease Digestive System Diseases ; 0.466 0.793
Alzheimer Disease, Late Onset Nervous System Diseases ; Mental Disorders ; 0.466 0.793
Acute Confusional Senile Dementia Nervous System Diseases ; Mental Disorders ; 0.466 0.793
Alzheimer's Disease, Focal Onset Nervous System Diseases ; Mental Disorders ; 0.466 0.793
Alzheimer Disease, Early Onset Nervous System Diseases ; Mental Disorders ; 0.466 0.793
Cerebral Infarction, Left Hemisphere Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Cerebral Infarction, Right Hemisphere Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Anterior Choroidal Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Subcortical Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Petrous Sinus Thrombophlebitis Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Intracranial Sinus Thrombophlebitis Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Petrous Sinus Thrombosis Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Acute Cerebrovascular Accidents Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Posterior Choroidal Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Cerebral Ischemia Nervous System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Mesenteric vascular insufficiency Digestive System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Venous Thromboembolism Cardiovascular Diseases ; 0.466 0.793
Liver carcinoma Neoplasms ; Digestive System Diseases ; 0.466 0.793
Steatohepatitis Digestive System Diseases ; 0.466 0.793
Factor II deficiency N/A 0.466 0.793
Nonalcoholic Steatohepatitis Digestive System Diseases ; 0.466 0.793
PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 2 N/A 0.466 0.793
Acute Mesenteric Arterial Embolus Digestive System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Occlusive Mesenteric Arterial Ischemia Digestive System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Nonocclusive Mesenteric Ischemia Digestive System Diseases ; Cardiovascular Diseases ; 0.466 0.793
Acute Mesenteric Arterial Thrombosis Digestive System Diseases ; Cardiovascular Diseases ; 0.466 0.793
NO RESULT FOUND
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