PLAU (GeneID: 5328) | Homo sapiens
Description: plasminogen activator, urokinase [Source:HGNC Symbol;Acc:HGNC:9052]
Synonyms: u-PA, ATF, URK, QPD, UPA, BDPLT5
Other ID(s): ENSG00000122861, HGNC:9052
Protein Accession Numbers: NP_002649, ENST00000481390, ENST00000372762, NP_001306120, ENST00000446342, NP_001138503, ENST00000372764
Statistics: gnomAD(96)
gnomAD Variants By Annotation

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000372762 ENST00000372764 ENST00000446342 ENST00000481390 NP_001138503 NP_001306120 NP_002649


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
NO DOMAINS EXIST

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Adenocarcinoma Neoplasms ; 0.434 0.69
Alzheimer's Disease Nervous System Diseases ; Mental Disorders ; 0.434 0.69
Angina Pectoris Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Angina, Unstable Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Anuria Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.434 0.69
Arterial Occlusive Diseases Cardiovascular Diseases ; 0.434 0.69
Asthma Respiratory Tract Diseases ; Immune System Diseases ; 0.434 0.69
Bone neoplasms Neoplasms ; Musculoskeletal Diseases ; 0.434 0.69
Cerebral Edema Nervous System Diseases ; 0.434 0.69
Carcinoma, Transitional Cell Neoplasms ; 0.434 0.69
Carotid Artery Diseases Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Intracranial Embolism and Thrombosis Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Cerebral Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Brain Ischemia Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Cerebrovascular Disorders Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Coronary heart disease Cardiovascular Diseases ; 0.434 0.69
Presenile dementia Nervous System Diseases ; Mental Disorders ; 0.434 0.69
IGA Glomerulonephritis Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; Immune System Diseases ; 0.434 0.69
Graft Occlusion, Vascular Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Heart Rupture, Post-Infarction Cardiovascular Diseases ; 0.434 0.69
Hematuria Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Hemorrhage Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Hypotension Cardiovascular Diseases ; 0.434 0.69
Ischemia Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Liver Cirrhosis Digestive System Diseases ; 0.434 0.69
Liver Cirrhosis, Experimental Digestive System Diseases ; 0.434 0.69
Malignant neoplasm of stomach Neoplasms ; Digestive System Diseases ; 0.434 0.69
Myocardial Infarction Cardiovascular Diseases ; 0.434 0.69
Neoplasm Invasiveness Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Neoplasm Metastasis Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Neoplasm Recurrence, Local Neoplasms ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Nephritis Male Urogenital Diseases ; Female Urogenital Diseases and Pregnancy Complications ; 0.434 0.69
Pancreatic Neoplasm Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.434 0.69
Prostatic Neoplasms Neoplasms ; Male Urogenital Diseases ; 0.434 0.69
Pulmonary Embolism Respiratory Tract Diseases ; Cardiovascular Diseases ; 0.434 0.69
Henoch-Schoenlein Purpura Cardiovascular Diseases ; Hemic and Lymphatic Diseases ; Immune System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Reperfusion Injury Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Stomach Neoplasms Neoplasms ; Digestive System Diseases ; 0.434 0.69
Cerebrovascular accident Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Thromboembolism Cardiovascular Diseases ; 0.434 0.69
Thrombosis Cardiovascular Diseases ; 0.434 0.69
Vasculitis, Hemorrhagic Cardiovascular Diseases ; Hemic and Lymphatic Diseases ; Immune System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Venous Thrombosis Cardiovascular Diseases ; 0.434 0.69
Ventricular Fibrillation Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Myocardial Preinfarction Syndrome Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Rheumatoid Purpura Cardiovascular Diseases ; Hemic and Lymphatic Diseases ; Immune System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Thrombus Cardiovascular Diseases ; 0.434 0.69
Cholesterol Embolism Cardiovascular Diseases ; 0.434 0.69
Deep Vein Thrombosis Cardiovascular Diseases ; 0.434 0.69
Intracranial Hemorrhages Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Adenocarcinoma, Basal Cell Neoplasms ; 0.434 0.69
Adenocarcinoma, Oxyphilic Neoplasms ; 0.434 0.69
Carcinoma, Cribriform Neoplasms ; 0.434 0.69
Carcinoma, Granular Cell Neoplasms ; 0.434 0.69
Adenocarcinoma, Tubular Neoplasms ; 0.434 0.69
Middle Cerebral Artery Syndrome Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Fibrosis, Liver Digestive System Diseases ; 0.434 0.69
Cerebrovascular Insufficiency Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Purpura, Nonthrombocytopenic Cardiovascular Diseases ; Hemic and Lymphatic Diseases ; Immune System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Familial Alzheimer Disease (FAD) Nervous System Diseases ; Mental Disorders ; 0.434 0.69
Malignant Bone Neoplasm Neoplasms ; Musculoskeletal Diseases ; 0.434 0.69
Sagittal Sinus Thrombosis Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Malignant neoplasm of pancreas Neoplasms ; Digestive System Diseases ; Endocrine System Diseases ; 0.434 0.69
Malignant neoplasm of prostate Neoplasms ; Male Urogenital Diseases ; 0.434 0.69
Purpura Hemorrhagica Cardiovascular Diseases ; Hemic and Lymphatic Diseases ; Immune System Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Asthenozoospermia Male Urogenital Diseases ; 0.434 0.69
Vasogenic Cerebral Edema Nervous System Diseases ; 0.434 0.69
Cytotoxic Cerebral Edema Nervous System Diseases ; 0.434 0.69
Alzheimer Disease, Late Onset Nervous System Diseases ; Mental Disorders ; 0.434 0.69
Pulmonary Thromboembolisms Respiratory Tract Diseases ; Cardiovascular Diseases ; 0.434 0.69
Acute Confusional Senile Dementia Nervous System Diseases ; Mental Disorders ; 0.434 0.69
Brain hemorrhage Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Carotid Atherosclerosis Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Cerebrovascular Occlusion Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
External Carotid Artery Diseases Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Middle Cerebral Artery Thrombosis Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Middle Cerebral Artery Occlusion Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Alzheimer's Disease, Focal Onset Nervous System Diseases ; Mental Disorders ; 0.434 0.69
Alzheimer Disease, Early Onset Nervous System Diseases ; Mental Disorders ; 0.434 0.69
Vasogenic Brain Edema Nervous System Diseases ; 0.434 0.69
Cytotoxic Brain Edema Nervous System Diseases ; 0.434 0.69
Internal Carotid Artery Diseases Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Arterial Diseases, Common Carotid Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Cerebral Infarction, Left Hemisphere Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Cerebral Infarction, Right Hemisphere Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Anterior Choroidal Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Subcortical Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Septic Phlebitis, Sagittal Sinus Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Sagittal Sinus Thrombophlebitis Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Middle Cerebral Artery Embolus Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Left Middle Cerebral Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Embolic Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Thrombotic Infarction, Middle Cerebral Artery Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Right Middle Cerebral Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Posterior Fossa Hemorrhage Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
Acute Cerebrovascular Accidents Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Cerebral Embolism and Thrombosis Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Posterior Choroidal Artery Infarction Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Cerebral Ischemia Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Brain Embolism and Thrombosis Nervous System Diseases ; Cardiovascular Diseases ; 0.434 0.69
Brain Edema Nervous System Diseases ; 0.434 0.69
Hereditary Diffuse Gastric Cancer Neoplasms ; Digestive System Diseases ; 0.434 0.69
Idiopathic Pulmonary Fibrosis Respiratory Tract Diseases ; 0.434 0.69
Quebec platelet disorder Hemic and Lymphatic Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.434 0.69
Cerebral Hemorrhage Nervous System Diseases ; Cardiovascular Diseases ; Pathological Conditions, Signs and Symptoms ; 0.434 0.69
NO RESULT FOUND
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