PDE4B (GeneID: 5142) | Homo sapiens
Description: phosphodiesterase 4B [Source:HGNC Symbol;Acc:HGNC:8781]
Synonyms: DPDE4, PDEIVB
Other ID(s): HGNC:8781, ENSG00000184588
Protein Accession Numbers: ENST00000371045, ENST00000531025, ENST00000491340, NP_001284370, ENST00000412480, NP_001032417, ENST00000341517, ENST00000528771, NP_002591, ENST00000480109, NP_001284369, ENST00000371049, NP_001032416, ENST00000329654, ENST00000526197, NP_001284371, ENST00000423207, NP_001032418
Statistics: gnomAD(82)
gnomAD Variants By Annotation

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000329654 ENST00000341517 ENST00000371045 ENST00000371049 ENST00000412480 ENST00000423207 ENST00000480109 ENST00000491340 ENST00000526197 ENST00000528771 ENST00000531025 NP_001032416 NP_001032417 NP_001032418 NP_001284369 NP_001284370 NP_001284371 NP_002591


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00233 PDEase_I 3''5''-cyclic nucleotide phosphodiesterase 405-645 CL0237 HD_PDEase Caenorhabditis elegans
PF18100 PDE4_UCR Phosphodiesterase 4 upstream conserved regions (UCR) 156-272 Caenorhabditis elegans

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Alcohol Use Disorder Chemically-Induced Disorders ; Mental Disorders ; 0.609 0.517
Alcoholic Intoxication, Chronic Chemically-Induced Disorders ; Mental Disorders ; 0.609 0.517
Asthma Respiratory Tract Diseases ; Immune System Diseases ; 0.609 0.517
Autistic Disorder Mental Disorders ; 0.609 0.517
Bipolar Disorder Mental Disorders ; 0.609 0.517
Depression, Bipolar Mental Disorders ; 0.609 0.517
Mental Depression Behavior and Behavior Mechanisms ; 0.609 0.517
Depressive disorder Mental Disorders ; 0.609 0.517
Leukemia, Myelocytic, Acute Neoplasms ; 0.609 0.517
Manic Disorder Mental Disorders ; 0.609 0.517
Acute Myeloid Leukemia, M1 Neoplasms ; 0.609 0.517
Schizophrenia Mental Disorders ; 0.609 0.517
Dermatologic disorders Skin and Connective Tissue Diseases ; 0.609 0.517
Alcohol abuse Chemically-Induced Disorders ; Mental Disorders ; 0.609 0.517
Myocardial Ischemia Cardiovascular Diseases ; 0.609 0.517
Amphetamine-Related Disorders Chemically-Induced Disorders ; Mental Disorders ; 0.609 0.517
Amphetamine Addiction Chemically-Induced Disorders ; Mental Disorders ; 0.609 0.517
Amphetamine Abuse Chemically-Induced Disorders ; Mental Disorders ; 0.609 0.517
Arsenic Poisoning, Inorganic Nervous System Diseases ; Chemically-Induced Disorders ; 0.609 0.517
Nervous System, Organic Arsenic Poisoning Nervous System Diseases ; Chemically-Induced Disorders ; 0.609 0.517
Arsenic Poisoning Nervous System Diseases ; Chemically-Induced Disorders ; 0.609 0.517
Manic Mental Disorders ; 0.609 0.517
Arsenic Encephalopathy Nervous System Diseases ; Chemically-Induced Disorders ; 0.609 0.517
Arsenic Induced Polyneuropathy Nervous System Diseases ; Chemically-Induced Disorders ; 0.609 0.517
Acute Myeloid Leukemia (AML-M2) Neoplasms ; 0.609 0.517
NO RESULT FOUND
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