FLT3 (GeneID: 2322) | Homo sapiens
Description: fms related tyrosine kinase 3 [Source:HGNC Symbol;Acc:HGNC:3765]
Synonyms: STK1, CD135, FLK2, FLK-2
Other ID(s): HGNC:3765, ENSG00000122025
Protein Accession Numbers: ENST00000241453, ENST00000380987, NP_004110, ENST00000380982, ENST00000537084
Statistics: gnomAD(716) COSMIC(1618)
gnomAD Variants By Annotation

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000241453 ENST00000380982 ENST00000380987 ENST00000537084 NP_004110


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00047 ig Immunoglobulin domain 256-346 CL0011 Ig Mus musculus
PF07714 PK_Tyr_Ser-Thr Protein tyrosine and serine/threonine kinase 611-946 CL0016 PKinase Mus musculus

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Burkitt Lymphoma Virus Diseases ; Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.503 0.517
Cytopenia N/A 0.503 0.517
Childhood Acute Lymphoblastic Leukemia Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.503 0.517
Leukemia, Lymphocytic, Acute, L2 Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.503 0.517
Acute biphenotypic leukemia Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.503 0.517
Leukemia, Myelocytic, Acute Neoplasms ; 0.503 0.517
Acute myelomonocytic leukemia Neoplasms ; 0.503 0.517
Acute Promyelocytic Leukemia Neoplasms ; 0.503 0.517
Leukocytosis Hemic and Lymphatic Diseases ; Pathological Conditions, Signs and Symptoms ; 0.503 0.517
Acute Myeloid Leukemia, M1 Neoplasms ; 0.503 0.517
Splenomegaly Pathological Conditions, Signs and Symptoms ; 0.503 0.517
Thrombosis Cardiovascular Diseases ; 0.503 0.517
Thrombus Cardiovascular Diseases ; 0.503 0.517
Pleocytosis Hemic and Lymphatic Diseases ; Pathological Conditions, Signs and Symptoms ; 0.503 0.517
Congenital anemia N/A 0.503 0.517
Acute myeloid leukemia, minimal differentiation N/A 0.503 0.517
Precursor B-cell lymphoblastic leukemia N/A 0.503 0.517
Acute Myeloid Leukemia (AML-M2) Neoplasms ; 0.503 0.517
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.503 0.517
Precursor Cell Lymphoblastic Leukemia Lymphoma Neoplasms ; Hemic and Lymphatic Diseases ; Immune System Diseases ; 0.503 0.517
AML M4 Eo with inv(16) or t(16;16) N/A 0.503 0.517
NO RESULT FOUND
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