KRT18 (GeneID: 3875) | Homo sapiens
Description: keratin 18 [Source:HGNC Symbol;Acc:HGNC:6430]
Synonyms: CK-18, K18, CYK18
Other ID(s): ENSG00000111057, HGNC:6430
Protein Accession Numbers: ENST00000388835.3, ENST00000550600, ENST00000388835, NP_954657, ENST00000388837, NP_000215
Statistics: gnomAD(408) COSMIC(223)
gnomAD Variants By Annotation

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000388835 ENST00000388837 ENST00000550600 NP_000215 NP_954657


import_contactsClinVar Data
Variation ID filter_list Allele ID filter_list RS Number filter_list Variant Type filter_list Record filter_list Alteration filter_list Clinicial Sig. filter_list Last Update filter_list Phenotypes filter_list Cytogenetic filter_list Review Status filter_list RCV Acc.N. filter_list

healinggnomAD
Variant ID filter_list Transcript ID filter_list Alteration filter_list Annotation filter_list Allele C. filter_list Allele N. filter_list Allele F. filter_list rsNumber filter_list Flagsfilter_list Filter filter_list

placePost-translational Modifications (PTMs)
Gene Name filter_list ACC ID filter_list PTM Type filter_list Position filter_list Mod-rsd filter_list Site +/-7 Aa filter_list Mw_kd filter_list Site grpID filter_list

blur_onCatalogue of Somatic Mutations in Cancer (COSMIC)
Gene Name filter_list Transcript ID filter_list Sample name filter_list Primary Site filter_list Primary Histology filter_list Mutation ID filter_list Mutation CDS filter_list Mutation Aa filter_list Mutation Desc. filter_list FATHMM Prediction filter_list FATHMM Score filter_list Mutation Somatic Status filter_list PUBMED PMID filter_list Tumor Origin filter_list Position filter_list

chrome_reader_modedbSNP
Gene ID filter_list Transcript ID filter_list Consequence filter_list Position filter_list HGVSp filter_list Impact filter_list

format_align_centerProtein Domains (PFAM)
Pfam Domain filter_list Domain Name filter_list Description filter_list Positions filter_list Clan filter_list Clan Name filter_list Organism filter_list
NO RESULT FOUND
PF00038 Filament Intermediate filament protein 71-384 Mus musculus

view_listList of the diseases from DisGeNET
Disease Name filter_list Disease Category filter_list DSI* filter_list DPI** filter_list
Malignant neoplasm of breast Neoplasms ; Skin and Connective Tissue Diseases ; 0.557 0.552
Hepatitis, Toxic Digestive System Diseases ; Chemically-Induced Disorders ; 0.557 0.552
Liver Cirrhosis Digestive System Diseases ; 0.557 0.552
Liver Cirrhosis, Experimental Digestive System Diseases ; 0.557 0.552
Liver neoplasms Neoplasms ; Digestive System Diseases ; 0.557 0.552
Necrosis Pathological Conditions, Signs and Symptoms ; 0.557 0.552
Liver Failure, Acute Digestive System Diseases ; 0.557 0.552
Fibrosis, Liver Digestive System Diseases ; 0.557 0.552
Cirrhosis, Cryptogenic Digestive System Diseases ; 0.557 0.552
Indian childhood cirrhosis Digestive System Diseases ; Respiratory Tract Diseases ; 0.557 0.552
Malignant neoplasm of liver Neoplasms ; Digestive System Diseases ; 0.557 0.552
Breast Carcinoma Neoplasms ; Skin and Connective Tissue Diseases ; 0.557 0.552
Drug-Induced Liver Disease Digestive System Diseases ; Chemically-Induced Disorders ; 0.557 0.552
Mammary Neoplasms, Human Neoplasms ; Skin and Connective Tissue Diseases ; 0.557 0.552
Hepatitis, Drug-Induced Digestive System Diseases ; Chemically-Induced Disorders ; 0.557 0.552
Mammary Neoplasms Neoplasms ; Skin and Connective Tissue Diseases ; 0.557 0.552
CIRRHOSIS, NONCRYPTOGENIC, SUSCEPTIBILITY TO (finding) N/A 0.557 0.552
COPPER TOXICOSIS, IDIOPATHIC Digestive System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Nutritional and Metabolic Diseases ; 0.557 0.552
Cirrhosis, Familial Digestive System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; 0.557 0.552
Copper-Overload Cirrhosis Digestive System Diseases ; Nervous System Diseases ; Congenital, Hereditary, and Neonatal Diseases and Abnormalities ; Nutritional and Metabolic Diseases ; 0.557 0.552
Endemic Tyrolean Infantile Cirrhosis Pathological Conditions, Signs and Symptoms ; 0.557 0.552
Drug-Induced Acute Liver Injury Digestive System Diseases ; Chemically-Induced Disorders ; 0.557 0.552
Chemical and Drug Induced Liver Injury Digestive System Diseases ; Chemically-Induced Disorders ; 0.557 0.552
Chemically-Induced Liver Toxicity Digestive System Diseases ; Chemically-Induced Disorders ; 0.557 0.552
NO RESULT FOUND
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