ConVarT

Pde4b (GeneID: 18578) | Mus musculus

Description:	phosphodiesterase 4B, cAMP specific [Source:MGI Symbol;Acc:MGI:99557]
Synonyms:	Dpde4, R74983, dunce
Other ID(s):	ENSMUSG00000028525, MGI:99557
Protein Accession Numbers:	NP_001171452, XP_017175518, XP_006502918, NP_001171454, XP_036019716, NP_001171451, XP_006502920, NP_062814, XP_036019718, NP_001171453, XP_017175519, XP_006502919, NP_001361709, XP_036019717
Statistics:

∙ Please click the name of species for the protein accession number used in the alignment.
∙ A p letter used as a pointer to positions of post translational modifications in human.
∙ Protein domains illustrated above belong to Homo sapiens (Human).
∙ ClinVar stacked bar chart represents whole protein isoforms of the gene. Please, check the other protein isoforms of the gene below.
∙ If more than one transcripts below are active (with blue background color), it means all the active transcripts have the same sequence.
ENST00000341517 ENST00000371045 ENST00000371049 ENST00000412480 ENST00000423207 ENST00000480109 ENST00000491340 ENST00000526197 ENST00000528771 ENST00000531025 NP_001032416 NP_001032417 NP_001032418 NP_001284369 NP_001284370 NP_001284371 NP_002591 ">ENST00000329654

ClinVar Data

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Variation ID	Allele ID	RS Number	Variant Type	Record	Alteration	Clinicial Sig.	Last Update	Phenotypes	Cytogenetic	Review Status	RCV Acc.N.

gnomAD

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Variant ID	Transcript ID	Alteration	Annotation	Allele C.	Allele N.	Allele F.	rsNumber	Flags	Filter
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Post-translational Modifications (PTMs)

Gene Name	ACC ID	PTM Type	Position	Mod-rsd	Site +/-7 Aa	Mw_kd	Site grpID

Catalogue of Somatic Mutations in Cancer (COSMIC)

Gene Name	Transcript ID	Sample name	Primary Site	Primary Histology	Mutation ID	Mutation CDS	Mutation Aa	Mutation Desc.	FATHMM Prediction	FATHMM Score	Mutation Somatic Status	PUBMED PMID	Tumor Origin	Position

dbSNP

Gene ID	Transcript ID	Consequence	Position	HGVSp	Impact

Protein Domains (PFAM)

Pfam Domain	Domain Name	Description	Positions	Clan	Clan Name	Organism
NO RESULT FOUND
PF00233	PDEase_I	3''5''-cyclic nucleotide phosphodiesterase	406-646	CL0237	HD_PDEase	Caenorhabditis elegans
PF18100	PDE4_UCR	Phosphodiesterase 4 upstream conserved regions (UCR)	157-273			Caenorhabditis elegans

List of the diseases from DisGeNET

Disease Name	Disease Category	DSI*	DPI**
Alcohol Use Disorder	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Alcoholic Intoxication, Chronic	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Asthma	Respiratory Tract Diseases ; Immune System Diseases ;	0.609	0.517
Autistic Disorder	Mental Disorders ;	0.609	0.517
Bipolar Disorder	Mental Disorders ;	0.609	0.517
Depression, Bipolar	Mental Disorders ;	0.609	0.517
Mental Depression	Behavior and Behavior Mechanisms ;	0.609	0.517
Depressive disorder	Mental Disorders ;	0.609	0.517
Leukemia, Myelocytic, Acute	Neoplasms ;	0.609	0.517
Manic Disorder	Mental Disorders ;	0.609	0.517
Acute Myeloid Leukemia, M1	Neoplasms ;	0.609	0.517
Schizophrenia	Mental Disorders ;	0.609	0.517
Dermatologic disorders	Skin and Connective Tissue Diseases ;	0.609	0.517
Alcohol abuse	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Myocardial Ischemia	Cardiovascular Diseases ;	0.609	0.517
Amphetamine-Related Disorders	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Amphetamine Addiction	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Amphetamine Abuse	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Arsenic Poisoning, Inorganic	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Nervous System, Organic Arsenic Poisoning	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Arsenic Poisoning	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Manic	Mental Disorders ;	0.609	0.517
Arsenic Encephalopathy	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Arsenic Induced Polyneuropathy	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Acute Myeloid Leukemia (AML-M2)	Neoplasms ;	0.609	0.517
NO RESULT FOUND

Classification of Clinicial Significance of ClinVar Data