ConVarT

ClinVar Data

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Variation ID	Allele ID	RS Number	Variant Type	Record	Alteration	Clinicial Sig.	Last Update	Phenotypes	Cytogenetic	Review Status	RCV Acc.N.

gnomAD

Frameshift Variant

Inframe Insertion

Missense Variant

Splice Acceptor Variant

Splice Region Variant

Stop Gained

Synonymous Variant

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Variant ID	Transcript ID	Alteration	Annotation	Allele C.	Allele N.	Allele F.	rsNumber
1-66379001-A-T	ENST00000329654	p.Lys2Ter	Stop Gained	0	0	0	rs781330175
1-66379001-A-T	ENST00000341517	p.Lys2Ter	Stop Gained	0	0	0	rs781330175
1-66379001-A-T	ENST00000371049	p.Lys2Ter	Stop Gained	0	0	0	rs781330175
1-66379006-A-G	ENST00000329654	p.Lys3Lys	Synonymous Variant	0	0	0	rs1483000794
1-66379006-A-G	ENST00000341517	p.Lys3Lys	Synonymous Variant	0	0	0	rs1483000794
1-66379006-A-G	ENST00000371049	p.Lys3Lys	Synonymous Variant	0	0	0	rs1483000794
1-66379015-T-A	ENST00000329654	p.Ser6Arg	Missense Variant	1	31346	0.000032	rs745869774
1-66379015-T-A	ENST00000341517	p.Ser6Arg	Missense Variant	1	31346	0.000032	rs745869774
1-66379015-T-A	ENST00000371049	p.Ser6Arg	Missense Variant	1	31346	0.000032	rs745869774
1-66379023-C-T	ENST00000329654	p.Thr9Met	Missense Variant	0	0	0	rs769931436
1-66379023-C-T	ENST00000341517	p.Thr9Met	Missense Variant	0	0	0	rs769931436
1-66379023-C-T	ENST00000371049	p.Thr9Met	Missense Variant	0	0	0	rs769931436
1-66379024-G-A	ENST00000329654	p.Thr9Thr	Synonymous Variant	2	31384	0.000064	rs200612585
1-66379024-G-A	ENST00000341517	p.Thr9Thr	Synonymous Variant	2	31384	0.000064	rs200612585
1-66379024-G-A	ENST00000371049	p.Thr9Thr	Synonymous Variant	2	31384	0.000064	rs200612585
1-66379025-G-A	ENST00000329654	p.Val10Met	Missense Variant	0	0	0	rs749546811
1-66379025-G-A	ENST00000341517	p.Val10Met	Missense Variant	0	0	0	rs749546811
1-66379025-G-A	ENST00000371049	p.Val10Met	Missense Variant	0	0	0	rs749546811
1-66379036-T-A	ENST00000329654	p.Asp13Glu	Missense Variant	0	0	0	rs144957956
1-66379036-T-A	ENST00000341517	p.Asp13Glu	Missense Variant	0	0	0	rs144957956

Showing 1 to 20 of 1,323 entries

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Post-translational Modifications (PTMs)

Acetylation

Methylation

Phosphorylation

Ubiquitination

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Gene Name	ACC ID	PTM Type	Position	Mod-rsd	Site +/-7 Aa	Mw_kd	Site grpID
PDE4B	Q07343	Phosphorylation	133	S133-p	GHSQRREsFLYRsDs	83.34	449097
PDE4B	Q07343	Phosphorylation	138	S138-p	REsFLYRsDsDyDLs	83.34	31864116
PDE4B	Q07343	Phosphorylation	140	S140-p	sFLYRsDsDyDLsPK	83.34	4765110
PDE4B	Q07343	Phosphorylation	142	Y142-p	LYRsDsDyDLsPKAM	83.34	15405168
PDE4B	Q07343	Phosphorylation	145	S145-p	sDsDyDLsPKAMSRN	83.34	468390
PDE4B	Q07343	Phosphorylation	197	S197-p	HGTSNKRsPAAsQPP	83.34	485071
PDE4B	Q07343	Phosphorylation	201	S201-p	NKRsPAAsQPPVSRV	83.34	485072
PDE4B	Q07343	Phosphorylation	214	S214-p	RVNPQEEsyQKLAME	83.34	23130419
PDE4B	Q07343	Phosphorylation	215	Y215-p	VNPQEEsyQKLAMET	83.34	23130425
PDE4B	Q07343	Ubiquitination	249	K249-ub	VSEMASNkFkRMLNR	83.34	21181042
PDE4B	Q07343	Methylation	251	K251-m1	EMASNkFkRMLNREL	83.34	57987357
PDE4B	Q07343	Phosphorylation	259	T259-p	RMLNRELtHLSEMSR	83.34	22640866
PDE4B	Q07343	Phosphorylation	290	S290-p	QNDVEIPsPTQKDRE	83.34	15721836
PDE4B	Q07343	Phosphorylation	309	S309-p	QQLMTQIsGVKKLMH	83.34	56657065
PDE4B	Q07343	Phosphorylation	319	S319-p	KKLMHSSsLNNTSIS	83.34	4765135
PDE4B	Q07343	Phosphorylation	520	S520-p	MVLATDMskHMSLLA	83.34	23130422
PDE4B	Q07343	Acetylation	521	K521-ac	VLATDMskHMSLLAD	83.34	6216773
PDE4B	Q07343	Acetylation	536	K536-ac	LKTMVETkkVTSSGV	83.34	3284598
PDE4B	Q07343	Acetylation	537	K537-ac	KTMVETkkVTSSGVL	83.34	9904835
PDE4B	Q07343	Phosphorylation	549	Y549-p	GVLLLDNyTDRIQVL	83.34	3672325

Showing 1 to 20 of 22 entries

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Catalogue of Somatic Mutations in Cancer (COSMIC)

Deletion - Frameshift

Insertion - Frameshift

Substitution - Coding Silent

Substitution - Missense

Substitution - Nonsense

Unknown

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Gene Name	Transcript ID	Sample name	Primary Site	Primary Histology	Mutation ID	Mutation CDS	Mutation Aa	Mutation Desc.	FATHMM Prediction	FATHMM Score	Mutation Somatic Status	PUBMED PMID	Tumor Origin	Position
PDE4B	ENST00000329654	8057490	pancreas	carcinoma	28634069	c.282-158193G>A	p.?	Unknown	NEUTRAL	.00027	Confirmed somatic variant	PMID: N/A	NS	0
PDE4B	ENST00000329654	8057490	pancreas	carcinoma	28634075	c.282-46674C>A	p.?	Unknown	NEUTRAL	.00256	Confirmed somatic variant	PMID: N/A	NS	0
PDE4B	ENST00000329654	FFPE-7	pancreas	carcinoma	28636060	c.634+198T>A	p.?	Unknown	NEUTRAL	.0196	Confirmed somatic variant	PMID: 29109526	primary	0
PDE4B	ENST00000329654	TCGA-EE-A3AG-06	skin	malignant_melanoma	28631687	c.305C>T	p.S102F	Substitution - Missense	PATHOGENIC	.92577	Confirmed somatic variant	PMID: N/A	NS	102
PDE4B	ENST00000329654	PCSI_0468_Pa_P_526	pancreas	carcinoma	28628526	c.282-66094T>C	p.?	Unknown	NEUTRAL	.03928	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	PCSI_0468_Pa_P_526	pancreas	carcinoma	28628533	c.842-2140T>A	p.?	Unknown	NEUTRAL	.19841	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	PCSI_0468_Pa_P_526	pancreas	carcinoma	28628524	c.282-160990C>A	p.?	Unknown	NEUTRAL	.03754	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	J32_T	lung	carcinoma	28638945	c.281+89645G>A	p.?	Unknown	NEUTRAL	.02074	Confirmed somatic variant	PMID: N/A	NS	0
PDE4B	ENST00000329654	RK234_C01	liver	carcinoma	28623736	c.*107C>T	p.?	Unknown	NEUTRAL	.10049	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	CPCG0240-F1	prostate	carcinoma	28631548	c.282-25241G>A	p.?	Unknown	NEUTRAL	.00082	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	LP6008280-DNA_A02	oesophagus	carcinoma	28641488	c.281+70247A>C	p.?	Unknown	NEUTRAL	.06317	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	PD24199a	breast	carcinoma	28631841	c.281+41922C>A	p.?	Unknown	NEUTRAL	.00712	Confirmed somatic variant	PMID: N/A	NS	0
PDE4B	ENST00000329654	PD11384a	breast	carcinoma	28641710	c.634+20784A>G	p.?	Unknown	NEUTRAL	.14332	Confirmed somatic variant	PMID: N/A	NS	0
PDE4B	ENST00000329654	LP6008280-DNA_A02	oesophagus	carcinoma	28641499	c.282-64860C>A	p.?	Unknown	NEUTRAL	.36843	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	RK234_C01	liver	carcinoma	28623732	c.477-4621A>T	p.?	Unknown	NEUTRAL	.02096	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	J32_T	lung	carcinoma	28638949	c.282-76175G>A	p.?	Unknown	NEUTRAL	.00284	Confirmed somatic variant	PMID: N/A	NS	0
PDE4B	ENST00000329654	PCSI_0468_Pa_P_526	pancreas	carcinoma	28628530	c.635-13686T>C	p.?	Unknown	NEUTRAL	.01752	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	LP6008280-DNA_A02	oesophagus	carcinoma	28641494	c.282-64861G>A	p.?	Unknown	PATHOGENIC	.73823	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	DN14011	breast	carcinoma	28634243	c.1385-606T>A	p.?	Unknown	NEUTRAL	.07574	Confirmed somatic variant	PMID: N/A	primary	0
PDE4B	ENST00000329654	PD13760a	breast	carcinoma	28626627	c.281+108362A>C	p.?	Unknown	NEUTRAL	.00164	Confirmed somatic variant	PMID: N/A	NS	0

Showing 1 to 20 of 3,093 entries

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dbSNP

Gene ID	Transcript ID	Consequence	Position	HGVSp	Impact

Protein Domains (PFAM)

Pfam Domain	Domain Name	Description	Positions	Clan	Clan Name	Organism
NO RESULT FOUND
PF00233	PDEase_I	3''5''-cyclic nucleotide phosphodiesterase	405-645	CL0237	HD_PDEase	Homo sapiens
PF18100	PDE4_UCR	Phosphodiesterase 4 upstream conserved regions (UCR)	166-281			Homo sapiens

List of the diseases from DisGeNET

Disease Name	Disease Category	DSI*	DPI**
Alcohol Use Disorder	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Alcoholic Intoxication, Chronic	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Asthma	Respiratory Tract Diseases ; Immune System Diseases ;	0.609	0.517
Autistic Disorder	Mental Disorders ;	0.609	0.517
Bipolar Disorder	Mental Disorders ;	0.609	0.517
Depression, Bipolar	Mental Disorders ;	0.609	0.517
Mental Depression	Behavior and Behavior Mechanisms ;	0.609	0.517
Depressive disorder	Mental Disorders ;	0.609	0.517
Leukemia, Myelocytic, Acute	Neoplasms ;	0.609	0.517
Manic Disorder	Mental Disorders ;	0.609	0.517
Acute Myeloid Leukemia, M1	Neoplasms ;	0.609	0.517
Schizophrenia	Mental Disorders ;	0.609	0.517
Dermatologic disorders	Skin and Connective Tissue Diseases ;	0.609	0.517
Alcohol abuse	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Myocardial Ischemia	Cardiovascular Diseases ;	0.609	0.517
Amphetamine-Related Disorders	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Amphetamine Addiction	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Amphetamine Abuse	Chemically-Induced Disorders ; Mental Disorders ;	0.609	0.517
Arsenic Poisoning, Inorganic	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Nervous System, Organic Arsenic Poisoning	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Arsenic Poisoning	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Manic	Mental Disorders ;	0.609	0.517
Arsenic Encephalopathy	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Arsenic Induced Polyneuropathy	Nervous System Diseases ; Chemically-Induced Disorders ;	0.609	0.517
Acute Myeloid Leukemia (AML-M2)	Neoplasms ;	0.609	0.517
NO RESULT FOUND

Description:	phosphodiesterase 4B, cAMP specific [Source:MGI Symbol;Acc:MGI:99557]
Synonyms:	Dpde4, R74983, dunce
Other ID(s):	ENSMUSG00000028525, MGI:99557
Protein Accession Numbers:	NP_001171452, XP_017175518, XP_006502918, NP_001171454, XP_036019716, NP_001171451, XP_006502920, NP_062814, XP_036019718, NP_001171453, XP_017175519, XP_006502919, NP_001361709, XP_036019717
Statistics:	ClinVar(10) gnomAD(1323) COSMIC(3093) PTM(22)

Classification of Clinicial Significance of ClinVar Data